Abstract Background The Drug Burden Index (DBI) measures an individual's total exposure
to anticholinergic and sedative medications. This systematic review aimed to investigate the …

Precision medicine is an approach to maximise the effectiveness of disease treatment and
prevention and minimise harm from medications by considering relevant demographic …

Aging, medication use, and global function are associated with changes in the microbiome.
However, their interrelationships and changes over time require further characterization. In a …

Aging and multimorbidity are associated with inflammation. Polypharmacy is common in
older people with multimorbidity. Given the potential for interactions between polypharmacy …

Incidence of anxiety-like disorders in humans has been shown to decrease with aging;
however, it is still under debate whether there are similarities in mice, which would support …

Background Ageing, sex and polypharmacy affect physical function. Objectives This mouse
study investigates how ageing, sex and polypharmacy interact and affect grip strength …

Alcohol use disorder (AUD) is a highly prevalent public health issue. Binge drinking is a very
common and harmful step in AUD. Yet, there are only 3 medications currently approved for …

Physiological changes associated with ageing can increase the susceptibility of older adults
to diseases, contributing to the rising prevalence of multimorbidity along with polypharmacy …

Aging, medication use, and global function are associated with changes in microbiome.
However, their interrelationships and changes over time require further characterisation. In a …