Evidence suggests that the perioperative period and the excision of the primary tumour can
promote the development of metastases—the main cause of cancer-related mortality. This …

Background The relationship between surgery and anesthetic-induced immunosuppression
and cancer recurrence remains unresolved. Surgery and anesthesia stimulate the …

Surgery is an important treatment modality for the majority of solid organ cancers.
Unfortunately, cancer recurrence following surgery of curative intent is common, and …

In patients with cancer, opioids are principally used for the management of acute surgical
and chronic cancer‐related pain. However, opioids have many non‐analgesic effects …

Cancer is a leading cause of morbidity and mortality worldwide and the ratio of incidence is
increasing. Mortality usually results from recurrence or metastases. Surgical removal of the …

IMMUNE PATHOGENESIS The principal line of defense against cancer cell invasion and
metastasis is established via the host's innate and adaptive immune response. The key …

Purpose Mortality among cancer patients is more commonly due to the effects of metastasis
and recurrence as opposed to the primary tumour. Various perioperative factors have been …

Recent epidemiologic studies implying differences in cancer recurrence based on
anesthetic regimens raise the possibility that the mu opioid receptor (MOR) can influence …

Background Morphine stimulates angiogenesis and cancer progression in mice. We
investigated whether morphine influences tumour onset, development, and animal model …

BACKGROUND Preclinical studies show that opioids stimulate angiogenesis and tumor
progression through the mu opioid receptor (MOR). Although MOR is overexpressed in …