During organogenesis, epithelial cells can give rise to mesenchymal cells through epithelial–
mesenchymal transition. The reverse process, mesenchymal–epithelial transition (MET), can …

Myeloid cells are crucial effectors of the innate immune response and important regulators of
adaptive immunity. The differentiation and activation of myeloid cells requires the timely …

Direct lineage reprogramming involves the conversion of cellular identity. Single-cell
technologies are useful for deconstructing the considerable heterogeneity that emerges …

Chromosomal architecture is known to influence gene expression, yet its role in controlling
cell fate remains poorly understood. Reprogramming of somatic cells into pluripotent stem …

Direct lineage reprogramming represents a remarkable conversion of cellular and
transcriptome states,,. However, the intermediate stages through which individual cells …

Here, we report DNA methylation and hydroxymethylation dynamics at nucleotide resolution
using C/EBPα-enhanced reprogramming of B cells into induced pluripotent cells (iPSCs) …

T cell development is orchestrated by transcription factors that regulate the expression of
genes initially buried within inaccessible chromatin, but the transcription factors that …

Epithelial-mesenchymal transition (EMT) and its critical roles during cancer progression
have long been recognized and extensively reviewed. Recent studies on the generation of …

Generation of induced pluripotent stem cells typically requires the ectopic expression of
transcription factors to reactivate the pluripotency network. However, it remains largely …

Stem cells have self-renewal capacities and the ability to give rise to differentiated cells
thereby sustaining tissues during homeostasis and injury. This structural hierarchy extends …