In situ tissue regeneration harnesses the body's regenerative potential to control cell
functions for tissue repair. The design of biomaterials for in situ tissue engineering requires …

Enabling angiogenesis is critical for the success of tissue repair therapies and the fate of
tissue-engineered constructs. Although many biochemical signaling molecules have been …

Abstract 3D tissue models recapitulating human physiology are important for fundamental
biomedical research, and they hold promise to become a new tool in drug development. An …

To promote vascularization of tissue-engineered bone, IFN-γ polarizing macrophages to M1
was loaded on 5% calcium silicate/β-tricalcium phosphate (CaSiO 3-β-TCP) scaffolds. IFN-γ …

Vascularization is a key event and also still a challenge in tissue engineering. Many efforts
have been devoted to the development of vascularization based on cells, growth factors …

Seriously compromised function of some organs can only be restored by transplantation.
Due to the shortage of human donors, the need to find another source of organs is of primary …

Extracellular matrix (ECM)-derived matrices such as Matrigel are used to culture numerous
cell types in vitro as they recapitulate ECM properties that support cell growth, organisation …

Growth factors (GFs) are versatile signalling molecules that orchestrate the dynamic, multi-
stage process of wound healing. Delivery of exogenous GFs to the wound milieu to mediate …

Materials science offers a powerful tool to control mesenchymal stem cell (MSC) growth and
differentiation into functional phenotypes. A complex interplay between the extracellular …

Mesenchymal stem cells, characterized by their ability to differentiate into skeletal tissues
and self-renew, hold great promise for both regenerative medicine and novel therapeutic …