PEGylation as a strategy for improving nanoparticle-based drug and gene delivery
Coating the surface of nanoparticles with polyethylene glycol (PEG), or “PEGylation”, is a
commonly used approach for improving the efficiency of drug and gene delivery to target …
commonly used approach for improving the efficiency of drug and gene delivery to target …
PEG—A versatile conjugating ligand for drugs and drug delivery systems
A Kolate, D Baradia, S Patil, I Vhora, G Kore… - Journal of controlled …, 2014 - Elsevier
Polyethylene glycol (PEG) conjugation is a rapidly evolving strategy to solve hurdles in
therapeutic delivery and is being used as an add-on tool to the traditional drug delivery …
therapeutic delivery and is being used as an add-on tool to the traditional drug delivery …
Polyethylene glycol immunogenicity: theoretical, clinical, and practical aspects of anti-polyethylene glycol antibodies
BM Chen, TL Cheng, SR Roffler - ACS nano, 2021 - ACS Publications
Polyethylene glycol (PEG) is a flexible, hydrophilic simple polymer that is physically attached
to peptides, proteins, nucleic acids, liposomes, and nanoparticles to reduce renal clearance …
to peptides, proteins, nucleic acids, liposomes, and nanoparticles to reduce renal clearance …
Anti-PEG antibodies before and after a first dose of Comirnaty®(mRNA-LNP-based SARS-CoV-2 vaccine)
Y Bavli, BM Chen, G Gross, A Hershko… - Journal of Controlled …, 2023 - Elsevier
The early and massive vaccination campaign in Israel with the mRNA-LNP
Comirnaty®(Pfizer-BioNTech) vaccine against the SARS-CoV-2 virus made available large …
Comirnaty®(Pfizer-BioNTech) vaccine against the SARS-CoV-2 virus made available large …
Antibodies against poly (ethylene glycol) activate innate immune cells and induce hypersensitivity reactions to PEGylated nanomedicines
WA Chen, DY Chang, BM Chen, YC Lin, Y Barenholz… - ACS …, 2023 - ACS Publications
Nanomedicines and macromolecular drugs can induce hypersensitivity reactions (HSRs)
with symptoms ranging from flushing and breathing difficulties to hypothermia, hypotension …
with symptoms ranging from flushing and breathing difficulties to hypothermia, hypotension …
[HTML][HTML] Anti-PEG antibodies enriched in the protein corona of PEGylated nanocarriers impact the cell uptake
MFS Deuker, V Mailänder, S Morsbach… - Nanoscale …, 2023 - pubs.rsc.org
Poly (ethylene glycol)(PEG) is the gold standard used to reduce unspecific protein
adsorption and prolong nanocarrier circulation time. However, this stealth effect could be …
adsorption and prolong nanocarrier circulation time. However, this stealth effect could be …
[HTML][HTML] Alzheimer's disease and the eye
RA Armstrong - Journal of Optometry, 2009 - Elsevier
Dementia, including Alzheimer's disease (AD), is a major disorder causing visual problems
in the elderly population. The pathology of AD includes the deposition in the brain of …
in the elderly population. The pathology of AD includes the deposition in the brain of …
Assessment of PEG on polymeric particles surface, a key step in drug carrier translation
JM Rabanel, P Hildgen, X Banquy - Journal of controlled release, 2014 - Elsevier
Injectable drug nanocarriers have greatly benefited in their clinical development from the
addition of a superficial hydrophilic corona to improve their cargo pharmacokinetics. The …
addition of a superficial hydrophilic corona to improve their cargo pharmacokinetics. The …
Polymer–drug conjugation, recent achievements and general strategies
G Pasut, FM Veronese - Progress in polymer science, 2007 - Elsevier
The field of drug delivery is fast expanding and its potentials have already been proved by
the many products in the market. Among all approaches, polymer conjugation is a well …
the many products in the market. Among all approaches, polymer conjugation is a well …
mRNA-1273 but not BNT162b2 induces antibodies against polyethylene glycol (PEG) contained in mRNA-based vaccine formulations
JM Carreño, G Singh, J Tcheou, K Srivastava… - Vaccine, 2022 - Elsevier
Two messenger RNA (mRNA)-based vaccines are widely used globally to prevent
coronavirus disease 2019 (COVID-19). Both vaccine formulations contain PEGylated lipids …
coronavirus disease 2019 (COVID-19). Both vaccine formulations contain PEGylated lipids …