Pancreatic ductal adenocarcinoma (PDAC) is commonly diagnosed when liver metastases
already emerged. We recently demonstrated that hepatic stromal cells determine the …

The microenvironment depends and generates dependence on all the cells and structures
that share the same niche, the biotope. The contemporaneous view of the tumor …

Growing by an alarming rate in the Western world, obesity has become a condition
associated with a multitude of diseases such as diabetes, metabolic syndrome and various …

Novel N, N-dialkyl carboxy coumarins have been synthesized as potential anticancer agents
via inhibition of monocarboxylate transporter 1 (MCT1). These coumarin carboxylic acids …

Recent studies in cancer metabolism directly implicate catabolic fibroblasts as a new rich
source of i) energy and ii) biomass, for the growth and survival of anabolic cancer cells …

Tumors are intricate ecosystems where cancer cells and non-malignant stromal cells,
including cancer-associated fibroblasts (CAFs), engage in complex communication. In this …

Anaplastic thyroid cancer (ATC) is one of the most aggressive human cancers. Key signal
transduction pathways that regulate mitochondrial metabolism are frequently altered in ATC …

Metformin is commonly used for treating type 2 diabetes, and may also reduce cancer risk.
Previous studies have demonstrated the association between metformin use and a …

Purpose: Monocarboxylate transporter 4 (MCT4) can influence the amount of lactate in the
tumor microenvironment and further control cancer cell proliferation, migration, and …

The tumor microenvironment is a complex mix of cancerous and noncancerous cells
(especially immune cells and fibroblasts) with distinct metabolisms. These cells interact with …