Malignant glioma represents a fatal disease with a poor prognosis and development of
resistance mechanisms against conventional therapeutic approaches. The distinct tumor …

Objectives Lactate as a key regulator of the glycolytic phenotype has been recently
described in fueling tumor growth and metastatic spread in head and neck squamous cell …

Objective The tumor microenvironment frequently displays abnormal cellular metabolism,
which contributes to aggressive behavior. Metformin inhibits mitochondrial oxidative …

Background Twenty percent of patients with classical Hodgkin Lymphoma (cHL) have
aggressive disease defined as relapsed or refractory disease to initial therapy. At present we …

Head and neck cancers (HNC) are a diverse group of aggressive malignancies with high
morbidity and mortality, leading to almost half-million deaths annually worldwide. A better …

Conventional therapeutics are often frequented with recurrences, refraction and regimen
resistance in oral cavity cancers which are predominantly manifested by cancer stem cells …

Simple Summary Lactic acidosis is a prominent feature of the tumour microenvironment and
a key player in cancer metabolism. This review is aimed at combining the mechanisms …

Citrate is a key metabolite of the Krebs cycle that can also be exported in the cytosol, where
it performs several functions. In normal cells, citrate sustains protein acetylation, lipid …

Hypoxia (oxygen deprivation) occurs in most solid malignancies, albeit with considerable
heterogeneity. Hypoxia is associated with an aggressive cancer phenotype by promotion of …

Here, we developed a model system to evaluate the metabolic effects of oncogene (s) on the
host microenvironment. A matched set of “normal” and oncogenically transformed epithelial …