Background: Metformin, an oral anti-hyperglycemic drug which inhibits mitochondrial
complex I and oxidative phosphorylation has been reported to correlate with improved …

Oral squamous cell carcinoma (OSCC) is the most common subsite of head and neck
cancer, with a 5-year survival rate of only 50%. There is a pressing need for animal models …

One important feature of tumour development is the regulatory role of metabolic plasticity in
maintaining the balance of mitochondrial oxidative phosphorylation and glycolysis in cancer …

Head and neck squamous cell carcinoma (HNSCC) is the 6th most common human cancer
and affects approximately 50,000 new patients every year in the US. The major risk factors …

Recent advances in the field of cancer metabolism raised awareness for the importance of
the tumour microenvironment in tumour growth and progression. The initial theory by …

Human head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer
type worldwide, possibly due to the significant role of alcohol and tobacco use in its …

Metabolite exchange between stromal and tumor cells or among tumor cells themselves
accompanies metabolic reprogramming in cancer including pancreatic adenocarcinoma …

Metabolic heterogeneity between neoplastic cells and surrounding stroma has been
described in several epithelial malignancies; however, the metabolic phenotypes of …

The lipoic acid (lipoate) coenzyme is unique in all of mammalian metabolism. It is not only
crucial to the function of some of the major enzymes feeding carbon into the tricarboxylic …

Pancreatic ductal adenocarcinoma (PDAC) is commonly diagnosed when liver metastases
already emerged. We recently demonstrated that hepatic stromal cells determine the …