Background Endometrial cancer (EC) is a major health concern due to its rising incidence.
Whilst early stage disease is generally cured by surgery, advanced EC has a poor prognosis …

Thyroid cancer (TC) is the most frequent endocrine tumor with a growing incidence
worldwide. Besides the improvement of diagnosis, TC increasing incidence is probably due …

Metabolic heterogeneity between neoplastic cells and surrounding stroma has been
described in several epithelial malignancies; however, the metabolic phenotypes of …

Recent advances in the field of cancer metabolism raised awareness for the importance of
the tumour microenvironment in tumour growth and progression. The initial theory by …

One important feature of tumour development is the regulatory role of metabolic plasticity in
maintaining the balance of mitochondrial oxidative phosphorylation and glycolysis in cancer …

Background Most in vitro cancer cell experiments have been performed using 2D models.
However, 3D spheroid cultures are increasingly favored for being more representative of in …

Despite clinical successes in the treatment of some early stage cancers, it is undeniable that
novel and innovative approaches are needed to aid in the fight against cancer. Targeted …

Glycolysis markers including glucose transporter 1 (GLUT1), monocarboxylate transporter 4
(MCT4), hexokinase 2 (HK2), pyruvate kinase M2 (PKM2) and glucose transporter 4 …

Mitochondria are critical for cellular survival, and for their proper functioning, translocation
of∼ 1500 proteins across the mitochondrial membranes is required. The translocase of the …

Aims. The preferential dependence on glycolysis as a pathway of energy metabolism is a
hallmark of cancer cells. However, the prognostic significance of glycolysis‐related genes in …