Ischemic stroke, a primary cause of disability and the second leading cause of mortality, has
emerged as an urgent public health issue. Growing evidence suggests that the Cyclic GMP …

Stimulator of interferon genes (STING) is an innate immune signaling protein critical to
infections, autoimmunity, and cancer. STING signaling is also emerging as an exciting and …

The cGAS–STING cytosolic double-stranded-DNA-sensing pathway provides protection
against infection but also contributes to inflammatory pathology and thus must be tightly …

The translocation of stimulator of interferon genes (STING) from the endoplasmic reticulum
(ER) to the ER–Golgi intermediate compartment (ERGIC) enables its activation. However …

Inflammation and pain are intertwined responses to injury, infection, or chronic diseases.
While acute inflammation is essential in determining pain resolution and opioid analgesia …

Extensive studies demonstrate the importance of the STING1 (also known as STING) protein
as a signaling hub that coordinates immune and autophagic responses to ectopic DNA in …

Pattern-recognition receptors (PRRs) are critical to recognizing endogenous and exogenous
threats to mount a protective proinflammatory innate immune response. PRRs may be …

The endothelium layer lining the inner surface of blood vessels serves relevant
physiological functions in all body systems, including the exchanges between blood and …

In the context of stroke and revascularization therapy, brain ischemia-reperfusion injury is a
significant challenge that leads to oxidative stress and inflammation. Central to the cell's …

The cGAS-STING pathway plays a crucial role in anti-tumoral responses by activating
inflammation and reprogramming the tumour microenvironment. Upon activation, STING …