Molecular and functional imaging in cancer-targeted therapy: current applications and future directions

JW Bai, SQ Qiu, GJ Zhang - Signal Transduction and Targeted Therapy, 2023 - nature.com
Targeted anticancer drugs block cancer cell growth by interfering with specific signaling
pathways vital to carcinogenesis and tumor growth rather than harming all rapidly dividing …

The world of rare interstitial lung diseases

K Buschulte, V Cottin, M Wijsenbeek… - European …, 2023 - Eur Respiratory Soc
The world of rare interstitial lung diseases (ILDs) is diverse and complex. Diagnosis and
therapy usually pose challenges. This review describes a selection of rare and ultrarare …

mTOR signaling network in cell biology and human disease

JJ Yu, EA Goncharova - International journal of molecular sciences, 2022 - mdpi.com
The mechanistic target of rapamycin (mTOR) is a serine/threonine protein kinase that
regulates multiple processes, including gene transcription, protein synthesis, ribosome …

Estradiol augments tumor-induced neutrophil production to promote tumor cell actions in lymphangioleiomyomatosis models

BMN Minor, D LeMoine, C Seger, E Gibbons… - …, 2023 - academic.oup.com
Lymphangioleiomyomatosis (LAM) is a rare cystic lung disease caused by smooth muscle
cell-like tumors containing tuberous sclerosis (TSC) gene mutations and found almost …

Lost in translation: a neglected mTOR target for lymphangioleiomyomatosis

JF Evans, FX McCormack, N Sonenberg… - European …, 2023 - Eur Respiratory Soc
Lymphangioleiomyomatosis (LAM) is a cystic lung disease of women resulting from
mutations in tuberous sclerosis complex (TSC) genes that suppress the mammalian target of …

[HTML][HTML] Clinical features and outcomes of male patients with lymphangioleiomyomatosis: a review

H Zhang, Z Hu, S Wang, K Wu, Q Yang, X Song - Medicine, 2022 - journals.lww.com
Background: Lymphangioleiomyomatosis (LAM) is a rare disease involving multiple
systems, which is divided into sporadic LAM (S-LAM) and tuberous sclerosis complex-LAM …

Probability of sporadic lymphangioleiomyomatosis in women presenting with spontaneous pneumothorax

A Suter, ME Mueller, C Daccord, P Taffé… - Orphanet journal of rare …, 2023 - Springer
Abstract Background Sporadic lymphangioleiomyomatosis (S-LAM) is a rare low-grade
neoplasm of young women characterized by multiple pulmonary cysts leading to …

Hyperactive mTORC1 in lung mesenchyme induces endothelial cell dysfunction and pulmonary vascular remodeling

SM Lin, R Rue, AR Mukhitov, A Goel… - The Journal of …, 2024 - Am Soc Clin Investig
Lymphangioleiomyomatosis (LAM) is a progressive cystic lung disease caused by tuberous
sclerosis complex 1/2 (TSC1/2) gene mutations in pulmonary mesenchymal cells, resulting …

Lymphangioleiomyomatosis: Where endocrinology, immunology and tumor biology meet

E Gibbons, BMN Minor… - Endocrine-related …, 2023 - erc.bioscientifica.com
Graphical abstract Abstract Lymphangioleiomyomatosis (LAM) is a cystic lung disease found
almost exclusively in genetic females and caused by small clusters of smooth muscle cell …

Safety and efficacy of cryobiopsy for the diagnosis of lymphangioleiomyomatosis compared with forceps biopsy and surgical lung biopsy

Y Yao, X Chen, H Chen, Z Xiao, S Li - BMC Pulmonary Medicine, 2023 - Springer
Background Transbronchial lung forceps biopsy (TBFB) is recommended before a surgical
lung biopsy (SLB) when a definitive diagnosis of lymphangioleiomyomatosis (LAM) is …