As a common clinical disease, neuropathic pain is difficult to be cured with drugs. The
occurrence and progression of pain is closely related to the response of spinal microglia. As …

Peripheral nerve injury elicits spinal microgliosis, contributing to neuropathic pain. The
aurora kinases A (AURKA), B (AURKB), and C (AURKC) are potential therapeutic targets in …

The experimental investigations on the pathogenesis of remifentanil-induced hyperalgesia
(RIH) have been primarily conducted, but the effective treatment of RIH remains unclear …

Abstract Ethnopharmacological relevance Qufeng Zhitong capsule (QFZTC) is a traditional
Chinese medicine (TCM) clinically used for treating pain. However, the active ingredients of …

Neuropathic pain is one of the important challenges in the clinic. Although a lot of research
has been done on neuropathic pain (NP), the molecular mechanism is still elusive. We …

Background Inflammation and immune activation may play a role in the pathological
mechanism of Major Depressive Disorder (MDD). Evidence from cross-sectional and …

Results LPS induced M1 polarization in BV-2 cells with increasing of CD86, iNOS and miR-
155, while IL-4 induced M2 polarization in BV-2 cells with increasing of CD206, Arg and …

Purpose This study aimed to examine electroacupuncture's influence on ocular pain and its
potential modulation of the TNF-ɑ mediated ERK1/2/P2X3R signaling pathway in dry eye …

Decrease of glutamate transporter-1 (GLT-1) in the spinal dorsal horn after nerve injury
induces enhanced excitatory transmission and causes persistent pain. Histone deacetylases …

At least in some individuals, the development of major depressive disorder (MDD) appears
to be significantly influenced by neuroinflammation. Microglia, which are situated within the …