The role of cancer-associated fibroblasts and fibrosis in liver cancer

S Affo, LX Yu, RF Schwabe - Annual Review of Pathology …, 2017 - annualreviews.org
Liver cancer is the second leading cause of cancer mortality worldwide, causing more than
700,000 deaths annually. Because of the wide landscape of genomic alterations and limited …

[HTML][HTML] The angiopoietin/Tie2 pathway in hepatocellular carcinoma

B Vanderborght, S Lefere, HV Vlierberghe… - Cells, 2020 - mdpi.com
Due to the usually late diagnosis and lack of effective therapies, hepatocellular carcinoma
(HCC), which poses a growing global health problem, is characterized by a poor prognosis …

Ceramide metabolism regulates autophagy and apoptotic cell death induced by melatonin in liver cancer cells

R Ordoñez, A Fernández… - Journal of pineal …, 2015 - Wiley Online Library
Autophagy is a process that maintains homeostasis during stress, although it also
contributes to cell death under specific contexts. Ceramides have emerged as important …

Fluorescence lifetime needle optical biopsy discriminates hepatocellular carcinoma

EA Zherebtsov, EV Potapova, AV Mamoshin… - Biomedical Optics …, 2022 - opg.optica.org
This work presents results of in vivo and in situ measurements of hepatocellular carcinoma
by a developed optical biopsy system. Here, we describe the technical details of the …

Chronic cadmium exposure at environmental-relevant level accelerates the development of hepatotoxicity to hepatocarcinogenesis

Y Xu, W Mu, J Li, Q Ba, H Wang - Science of the Total Environment, 2021 - Elsevier
Cadmium (Cd) is an environmental heavy metal with long biological half-time and adverse
health effects. The long-term toxicity of Cd at low levels remains to be elucidated. Here, we …

[HTML][HTML] Machine learning identifies ferroptosis-related gene ANXA2 as potential diagnostic biomarkers for NAFLD

J Qin, P Cao, X Ding, Z Zeng, L Deng… - Frontiers in …, 2023 - frontiersin.org
Introduction Non-alcoholic fatty liver disease (NAFLD), a major cause of chronic liver
disease, still lacks effective therapeutic targets today. Ferroptosis, a type of cell death …

Harmine induces apoptosis in HepG2 cells via mitochondrial signaling pathway

MR Cao, Q Li, ZL Liu, HH Liu, W Wang, XL Liao… - … & pancreatic diseases …, 2011 - Elsevier
Background Harmine has antitumor and antinociceptive effects, and inhibits human DNA
topoisomerase. However, no detailed data are available on the mechanisms of action of …

A Huaier polysaccharide restrains hepatocellular carcinoma growth and metastasis by suppression angiogenesis

C Li, X Wu, H Zhang, G Yang, M Hao, S Sheng… - International journal of …, 2015 - Elsevier
Hepatocellular carcinoma (HCC) is a highly metastatic cancer. Huaier polysaccharide (TP-1)
is a naturally occurring bioactive macromolecule, found in Huaier fungus and has been …

Targeting molecular signal transduction pathways in hepatocellular carcinoma and its implications for cancer therapy

IH Mir, S Guha, J Behera… - Cell Biology …, 2021 - Wiley Online Library
Hepatocellular carcinoma is a substantial health concern. It is currently the third dominating
cause of mortality associated with cancer worldwide. The development of hepatocellular …

[HTML][HTML] Expression of microRNA-150 targeting vascular endothelial growth factor-A is downregulated under hypoxia during liver regeneration

ZY Yu, YN Bai, LX Luo, H Wu… - Molecular Medicine …, 2013 - spandidos-publications.com
Vascular endothelial growth factor (VEGF) is a factor that stimulates the proliferation of
sinusoidal endothelial cells and hepatocytes during liver regeneration (LR). The present …