Environmental impacts of the industrial revolution necessitate adoption of sustainable
practices in all areas of development. The pharmaceutical industry faces increasing …

The risk assessment and control of N-nitrosamine impurities in medicines is a topic of great
concern for patients, regulators, and the pharmaceutical industry. This paper discusses a …

This chapter summarizes the beginnings of supramolecular chemistry and crystal
engineering from the early 1990s to the supramolecular synthon, then leading to cocrystals …

In the pharmaceutical area, to obtain structures with desired properties, one can design and
perform a screening of multicomponent forms of a drug. However, there is an infinite number …

Major constraints in development of new product are poor aqueous solubility, stability and
low oral bioavailability, low permeability. As majority of drugs marketed worldwide are …

Thirty-four binary systems of nitrofurantoin with pyridine derivatives were analyzed by
combining virtual (molecular complementarity prediction and hydrogen bond propensity …

Various drugs are not able to reach the market due to their poor bioavailability and poor
solubility in aqueous media. Hence, several approaches are used to enhance the solubility …

Belinostat is a histone deacetylase inhibitor for the treatment of refractory T-cell lymphoma.
Our study found that the tendency to form solvates of belinostat with hydrogen-bond …

There are very few articles that investigate the thermodynamic formation of two-component
molecular crystals. For this reason, it is difficult to conduct a statistically meaningful …

The pharmaceutical cocrystal landscape of ethenzamide has been addressed during the
past years with the aim of improving its physicochemical properties, mainly solubility and …