Engineered extracellular vesicles and their mimetics for cancer immunotherapy

C Liu, Y Wang, L Li, D He, J Chi, Q Li, Y Wu… - Journal of Controlled …, 2022 - Elsevier
Extracellular vesicles (EVs) are heterogeneous membranous vesicles secreted by living
cells that are involved in many physiological and pathological processes as intermediaries …

[HTML][HTML] Extracellular vesicles in ovarian cancer chemoresistance, metastasis, and immune evasion

W Tian, N Lei, J Zhou, M Chen, R Guo, B Qin, Y Li… - Cell Death & …, 2022 - nature.com
Chemoresistance and metastasis are the major challenges for the current ovarian cancer
treatment. Understanding the mechanisms of ovarian cancer progression and metastasis is …

[HTML][HTML] Scalable production of extracellular vesicles and its therapeutic values: a review

CY Ng, LT Kee, ME Al-Masawa, QH Lee… - International Journal of …, 2022 - mdpi.com
Extracellular vesicles (EVs) are minute vesicles with lipid bilayer membranes. EVs are
secreted by cells for intercellular communication. Recently, EVs have received much …

[HTML][HTML] Nanocarriers surface engineered with cell membranes for cancer targeted chemotherapy

W Lei, C Yang, Y Wu, G Ru, X He, X Tong… - Journal of …, 2022 - Springer
Background Inspired by nature, the biomimetic approach has been incorporated into drug
nanocarriers for cancer targeted chemotherapy. The nanocarriers are cloaked in cell …

Cell-derived biomimetic nanocarriers for targeted cancer therapy: cell membranes and extracellular vesicles

A Li, Y Zhao, Y Li, L Jiang, Y Gu, J Liu - Drug Delivery, 2021 - Taylor & Francis
Nanotechnology provides synthetic carriers for cancer drug delivery that protect cargos from
degradation, control drug release and increase local accumulation at tumors. However …

Exosome-based nanomedicine for cancer treatment by targeting inflammatory pathways: current status and future perspectives

MA Ansari, M Thiruvengadam, B Venkidasamy… - Seminars in cancer …, 2022 - Elsevier
Cancer is one of the dreadful diseases worldwide. Surgery, radiation and chemotherapy, are
the three basic standard modes of cancer treatment. However, difficulties in cancer treatment …

Biomimetic immunomodulation strategies for effective tissue repair and restoration

RA Villarreal-Leal, GD Healey, B Corradetti - Advanced drug delivery …, 2021 - Elsevier
Inflammation plays a central role in wound healing following injury or disease and is
mediated by a precise cascade of cellular and molecular events. Unresolved inflammatory …

Mesenchymal stem cells, exosomes and exosome-mimics as smart drug carriers for targeted cancer therapy

H Liu, S Deng, L Han, Y Ren, J Gu, L He, T Liu… - Colloids and Surfaces B …, 2022 - Elsevier
Mesenchymal stem cells (MSCs) are multipotent stem cells with the capacity to differentiate
into several cell types under appropriate conditions. They also possess remarkable …

Immune-cell-derived exosomes for cancer therapy

Y Zhao, T Liu, M Zhou - Molecular pharmaceutics, 2022 - ACS Publications
Exosomes are a type of extracellular vesicles secreted by cells in normal or pathological
conditions for cell–cell communication. With immunomodulatory characteristics and potential …

[HTML][HTML] Exosomes derived from 3D-cultured MSCs improve therapeutic effects in periodontitis and experimental colitis and restore the Th17 cell/Treg balance in …

Y Zhang, J Chen, H Fu, S Kuang, F He… - International journal of …, 2021 - nature.com
Although mesenchymal stem cell-derived exosomes (MSC-exos) have been shown to have
therapeutic effects in experimental periodontitis, their drawbacks, such as low yield and …