Although acute exposure of the heart to angiotensin (Ang II) produces physiological cardiac
hypertrophy and chronic exposure results in pathological hypertrophy, the signal …

With cardiovascular disease (CVD) being a primary source of global morbidity and mortality,
it is crucial that we understand the molecular pathophysiological mechanisms at play …

Around the world there are 33.5 million patients suffering from atrial fibrillation (AF) with an
annual increase of 5 million cases. Most AF patients have an established form of an atrial …

Metformin, a well‐known AMPK agonist, has been widely used as the first‐line drug for
treating type 2 diabetes. There had been a significant concern regarding the use of …

Background Therapies are urgently required to ameliorate pathological cardiac hypertrophy
and enhance cardiac function in heart failure. Our preliminary experiments have …

Ischemia-reperfusion (I/R) injury is well-known to be associated with impaired cardiac
function, massive arrhythmias, marked alterations in cardiac metabolism and irreversible …

Mitochondria are specialized organelles, which serve as the “Power House” to generate
energy for maintaining heart function. These organelles contain various enzymes for the …

It is now well known that oxidative stress promotes lipid peroxidation, protein oxidation,
activation of proteases, fragmentation of DNA and alteration in gene expression for …

Cardiovascular diseases are currently the primary cause of mortality in the whole world.
Growing evidence indicated that the disturbances in cardiac fatty acid metabolism are …

Free radicals and oxidants may cause various damages both to the lifeworld and different
products. A typical solution for the prophylaxis of oxidation-caused conditions is the usage of …