C3‐dependent effector functions of complement
A Zarantonello, M Revel, A Grunenwald… - Immunological …, 2023 - Wiley Online Library
C3 is the central effector molecule of the complement system, mediating its multiple
functions through different binding sites and their corresponding receptors. We will introduce …
functions through different binding sites and their corresponding receptors. We will introduce …
[HTML][HTML] Defining blood-induced microglia functions in neurodegeneration through multiomic profiling
Blood protein extravasation through a disrupted blood–brain barrier and innate immune
activation are hallmarks of neurological diseases and emerging therapeutic targets …
activation are hallmarks of neurological diseases and emerging therapeutic targets …
[HTML][HTML] Mechanisms of host manipulation by Neisseria gonorrhoeae
Neisseria gonorrhoeae (also known as gonococcus) has been causing gonorrhoea in
humans since ancient Egyptian times. Today, global gonorrhoea infections are rising at an …
humans since ancient Egyptian times. Today, global gonorrhoea infections are rising at an …
CD11b agonists offer a novel approach for treating lupus nephritis
Lupus nephritis (LN) develops in more than a third of all systemic lupus erythematosus
(SLE) patients and is the strongest predictor of morbidity and mortality. Increased circulating …
(SLE) patients and is the strongest predictor of morbidity and mortality. Increased circulating …
Reduced binding of apoE4 to complement factor H promotes amyloid‐β oligomerization and neuroinflammation
L Chernyaeva, G Ratti, L Teirilä, S Fudo, U Rankka… - EMBO …, 2023 - embopress.org
The APOE4 variant of apolipoprotein E (apoE) is the most prevalent genetic risk allele
associated with late‐onset Alzheimer's disease (AD). ApoE interacts with complement …
associated with late‐onset Alzheimer's disease (AD). ApoE interacts with complement …
[HTML][HTML] Structural biology of complement receptors
J Santos-López, K De la Paz, FJ Fernández… - Frontiers in …, 2023 - frontiersin.org
The complement system plays crucial roles in a wide breadth of immune and inflammatory
processes and is frequently cited as an etiological or aggravating factor in many human …
processes and is frequently cited as an etiological or aggravating factor in many human …
Understanding the immunological interactions of engineered nanomaterials: Role of the bio‐corona
B Fadeel - Wiley Interdisciplinary Reviews: Nanomedicine and …, 2022 - Wiley Online Library
Engineered nanomaterials are a broad class of materials with the potential for breakthrough
applications in many sectors of society not least in medicine. Consequently, safety …
applications in many sectors of society not least in medicine. Consequently, safety …
[HTML][HTML] The complement system as a regulator of tumor-promoting activities mediated by myeloid-derived suppressor cells
Tumor progression relies on the interaction between tumor cells and their surrounding tumor
microenvironment (TME), which also influences therapeutic responses. The complement …
microenvironment (TME), which also influences therapeutic responses. The complement …
Immunomodulatory activity of Senegalia macrostachya (Reichenb. ex DC.) Kyal. & Boatwr seed polysaccharide fraction through the activation of the MAPK signaling …
Senegalia macrostachya (Reichenb. ex DC.) Kyal. & Boatwr seed (SMS) is a wild legume
used as food and medicine in many African countries. In the current study, a novel …
used as food and medicine in many African countries. In the current study, a novel …
Phagocytosis via complement receptor 3 enables microbes to evade killing by neutrophils
Abstract CR3 (CD11b/CD18; αmβ2 integrin) is a conserved phagocytic receptor. The active
conformation of CR3 binds the iC3b fragment of complement C3 as well as many host and …
conformation of CR3 binds the iC3b fragment of complement C3 as well as many host and …