Per‐and poly‐fluoroalkyl substances (PFAS) encompass a large, heterogenous group of
chemicals of potential concern to human health and the environment. Based on information …

While human regulatory risk assessment (RA) still largely relies on animal studies, new
approach methodologies (NAMs) based on in vitro, in silico or non-mammalian alternative …

Tire wear particles (TWP) have become the major microplastic pollution in China. Road
runoff containing TWP leachate can decrease the eye size and even induced mortality in the …

Endocrine disrupting chemicals (EDCs) are found in every environmental medium and are
chemically diverse. Their presence in water resources can negatively impact the health of …

Identification of thyroid disrupting chemicals (TDCs), one of the most studied types of
endocrine disruptors (EDs), is required according to EU regulations on industrial chemicals …

Thyroid hormone system disrupting compounds are considered potential threats for human
and environmental health. Multiple adverse outcome pathways (AOPs) for thyroid hormone …

Thyroid hormone system disruption (THSD) negatively affects multiple developmental
processes and organs. In fish, inhibition of deiodinases, which are enzymes crucial for (in) …

Thousands of contaminants are used worldwide and eventually released into the
environment, presenting a challenge of health risk assessment. The identification of key …

Chemical pollution from plasticizers in water environments is a serious environmental
problem worldwide. Phthalate plasticizers have potential endocrine-disrupting effects in …

Endocrine disrupting chemicals (EDCs) are ubiquitous in the environment and involve
diverse chemical-receptor interactions that can perturb hormone signaling. The Organization …