The human CNS follows a pattern of development typical of all mammals, but certain
neurodevelopmental features are highly derived. Building the human CNS requires the …

Understanding brain circuits begins with an appreciation of their component parts—the cells.
Although GABAergic interneurons are a minority population within the brain, they are crucial …

Diverse types of glutamatergic pyramidal neurons mediate the myriad processing streams
and output channels of the cerebral cortex,, yet all derive from neural progenitors of the …

Classical lissencephaly is a genetic neurological disorder associated with mental
retardation and intractable epilepsy, and Miller-Dieker syndrome (MDS) is the most severe …

INTRODUCTION The mammalian neocortex, with its distinctive six-layered structure, is
thought to enable advanced cognitive functions not seen in other animals. Yet birds, which …

Craniosynostosis results from premature fusion of the cranial suture (s), which contain
mesenchymal stem cells (MSCs) that are crucial for calvarial expansion in coordination with …

Corticostriatal projections are essential components of forebrain circuits and are widely
involved in motivated behaviour. These axonal projections are formed by two distinct …

Over the past several decades, significant advances have been made in our understanding
of the basic stages and mechanisms of mammalian brain development. Studies elucidating …

The scarcity of live human brain cells for experimental access has for a long time limited our
ability to study complex human neurological disorders and elucidate basic neuroscientific …

The study of human cortical development has major implications for brain evolution and
diseases but has remained elusive due to paucity of experimental models. Here we found …