Regulations of xenobiotics and endobiotics on carboxylesterases: a comprehensive review
Y Xu, C Zhang, W He, D Liu - European journal of drug metabolism and …, 2016 - Springer
Carboxylesterases (CESs) play major roles in catalyzing the hydrolysis of a wide range of
ester-and amide-containing compounds. CESs dominate both the biotransformation of …
ester-and amide-containing compounds. CESs dominate both the biotransformation of …
A red lysosome-targeted fluorescent probe for carboxylesterase detection and bioimaging
H Zhou, J Tang, J Zhang, B Chen, J Kan… - Journal of Materials …, 2019 - pubs.rsc.org
In this study, a new red lysosome-targeted fluorescence off–on probe has been rationally
designed, synthesized and applied for the highly selective and sensitive fluorescence …
designed, synthesized and applied for the highly selective and sensitive fluorescence …
Regulation of carboxylesterases and its impact on pharmacokinetics and pharmacodynamics: an up-to-date review
ABSTRACT Introduction Carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2) are
among the most abundant hydrolases in humans, catalyzing the metabolism of numerous …
among the most abundant hydrolases in humans, catalyzing the metabolism of numerous …
Development of a near-infrared fluorescent probe with large Stokes shift for carboxylesterases detection and its application in living systems
J Zhang, Y Peng, Y Li, N Wang, Y Chai, C Qin… - Dyes and …, 2022 - Elsevier
Accurate detection of carboxylesterases (CEs) plays a crucial role in various disease
physiological processes and ester-containing drug metabolism. However, the reported near …
physiological processes and ester-containing drug metabolism. However, the reported near …
Design, synthesis, and evaluation of a carboxylesterase detection probe with therapeutic effects
X Lin, M Liu, Q Yi, Y Zhou, J Su, B Qing, Y Lu, C Pu… - Talanta, 2024 - Elsevier
In this study, a lysosomal targeting fluorescent probe recognition on CEs was designed and
synthesized. The obtained probe BF 2-cur-Mor demonstrated excellent selectivity, sensitivity …
synthesized. The obtained probe BF 2-cur-Mor demonstrated excellent selectivity, sensitivity …
Dihydroxanthene-derived fluorescent probe with near-infrared excitation and emission maxima for detecting human carboxylesterase-2 and bioimaging
B Yang, X Ding, J Li, J Lai, Z Zhang, X Xu, Z Liu… - Sensors and Actuators B …, 2023 - Elsevier
Carboxylesterases in human body play pivotal roles for catalyzing the hydrolysis of
endogenous and exogenous substances such as lipids, thioesters and amides …
endogenous and exogenous substances such as lipids, thioesters and amides …
An ultrasensitive and selective near-infrared fluorescent probe for tracking carboxylesterases with large Stokes shift in living cells and mice
W Zhang, C Qi, X Wang, Z Fu, J Zhang, Y Zhou… - … Acta Part A: Molecular …, 2024 - Elsevier
Carboxylesterases (CEs) play great role in CEs-related diseases and drug metabolism.
Selectively monitoring its activity is important to explore its role in CEs-related diseases and …
Selectively monitoring its activity is important to explore its role in CEs-related diseases and …
A novel indene-chalcone-based fluorescence probe with lysosome-targeting for detection of endogenous carboxylesterases and bioimaging
L Zhang, JL Yan, Y Wang, XL Zhao, WN Wu… - … Acta Part A: Molecular …, 2022 - Elsevier
An indene-chalcone-based fluorescence probe 1 was synthesized and characterized. Under
physiological conditions (containing 5% DMSO), probe 1 showed satisfactory stability with a …
physiological conditions (containing 5% DMSO), probe 1 showed satisfactory stability with a …
[HTML][HTML] IL-33 downregulates hepatic carboxylesterase 1 in acute liver injury via macrophage-derived exosomal miR-27b-3p
P Gao, M Li, J Lu, D Xiang, X Wang, Y Xu… - Journal of Clinical …, 2023 - ncbi.nlm.nih.gov
Methods IL-33 and CES1 levels were determined in the livers of patients and
lipopolysaccharide (LPS)-, acetaminophen (APAP)-treated mice. We constructed IL-33 and …
lipopolysaccharide (LPS)-, acetaminophen (APAP)-treated mice. We constructed IL-33 and …
Suppression of carboxylesterases by imatinib mediated by the down‐regulation of pregnane X receptor
W Luo, Y Xin, X Zhao, F Zhang, C Liu… - British Journal of …, 2017 - Wiley Online Library
Background and Purpose Imatinib mesylate (IM) is a first‐line treatment for chronic myeloid
leukaemia (CML) as a specific inhibitor of BCR‐ABL tyrosine kinase. As IM is widely used in …
leukaemia (CML) as a specific inhibitor of BCR‐ABL tyrosine kinase. As IM is widely used in …