Artificial intelligence for biomarker discovery in Alzheimer's disease and dementia

LM Winchester, EL Harshfield, L Shi… - Alzheimer's & …, 2023 - Wiley Online Library
With the increase in large multimodal cohorts and high‐throughput technologies, the
potential for discovering novel biomarkers is no longer limited by data set size. Artificial …

Clinical trials in dementia with Lewy bodies: the evolving concept of co-pathologies, patient selection and biomarkers

LL Gibson, C Abdelnour, J Chong… - Current Opinion in …, 2023 - journals.lww.com
Clinical trials in dementia with Lewy bodies: the evolving c... : Current Opinion in Neurology
Clinical trials in dementia with Lewy bodies: the evolving concept of co-pathologies, patient …

Plasma brain-derived tau is an amyloid-associated neurodegeneration biomarker in Alzheimer's disease

F Gonzalez-Ortiz, BE Kirsebom, J Contador… - Nature …, 2024 - nature.com
Staging amyloid-beta (Aβ) pathophysiology according to the intensity of neurodegeneration
could identify individuals at risk for cognitive decline in Alzheimer's disease (AD). In blood …

Head-to-head study of diagnostic accuracy of plasma and cerebrospinal fluid p-tau217 versus p-tau181 and p-tau231 in a memory clinic cohort

AJ Mendes, F Ribaldi, A Lathuiliere, NJ Ashton… - Journal of …, 2024 - Springer
Background and objective Phosphorylated tau (p-tau) 217 has recently received attention
because it seems more reliable than other p-tau variants for identifying Alzheimer's disease …

Plasma p-tau212 antemortem diagnostic performance and prediction of autopsy verification of Alzheimer's disease neuropathology

PR Kac, F González-Ortiz, A Emeršič… - Nature …, 2024 - nature.com
Blood phosphorylated tau (p-tau) biomarkers, including p-tau217, show high associations
with Alzheimer's disease (AD) neuropathologic change and clinical stage. Certain plasma p …

A cross-sectional study of Alzheimer-related proteins in women with polycystic ovary syndrome

AE Butler, ASM Moin, T Sathyapalan… - International Journal of …, 2024 - mdpi.com
Polycystic ovary syndrome (PCOS) is the most common endocrine condition in women of
reproductive age, and several risk factors found in PCOS are associated with an increased …

A novel ultrasensitive assay for plasma p‐tau217: performance in individuals with subjective cognitive decline and early Alzheimer's disease

F Gonzalez‐Ortiz, PCL Ferreira… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Detection of Alzheimer's disease (AD) pathophysiology among individuals
with mild cognitive changes and those experiencing subjective cognitive decline (SCD) …

Novel aspects of the phosphorylation and structure of pathological tau: implications for tauopathy biomarkers

T Kimura, H Sato, M Kano, L Tatsumi… - FEBS Open bio, 2024 - Wiley Online Library
The deposition of highly phosphorylated and aggregated tau is a characteristic of
tauopathies, including Alzheimer's disease. It has long been known that different isoforms of …

Combining plasma Aβ and p-tau217 improves detection of brain amyloid in non-demented elderly

Y Niimi, S Janelidze, K Sato, N Tomita… - Alzheimer's Research & …, 2024 - Springer
Background Maximizing the efficiency to screen amyloid-positive individuals in
asymptomatic and non-demented aged population using blood-based biomarkers is …

Exploring the potential of fully automated LUMIPULSE G plasma assays for detecting Alzheimer's disease pathology

A Silva-Spínola, MJ Leitão, A Nadal… - Alzheimer's Research & …, 2024 - Springer
Background LUMIPULSE G-automated immunoassays represent a widely used method for
the quantification of Alzheimer's disease (AD) biomarkers in the cerebrospinal fluid (CSF) …