Abstract Treatment resistant schizophrenia (TRS) refers to the significant proportion of
schizophrenia patients who continue to have symptoms and poor outcomes despite …

Second-generation antipsychotics (SGAs) are the cornerstone of treatment for schizophrenia
because of their high clinical efficacy. However, SGA treatment is associated with severe …

Almost fifty years after its first introduction into clinical care, clozapine remains the only
evidence-based pharmacological option for treatment-resistant schizophrenia (TRS), which …

Clozapine is superior to other antipsychotics as a therapy for treatment-resistant
schizophrenia and schizoaffective disorder with increased risk of suicidal behavior. This …

Psychiatric genomics is providing insights into the nature of psychiatric conditions that in
time should identify new drug targets and improve patient care. Less attention has been paid …

Compounds known to be successful in the treatment of alcohol use disorder include the
aversive agent, Disulfiram, the glutamatergic NMDA receptor antagonist, Acamprosate, and …

Clozapine is considered «the golden standard» for the management of treatment-resistant
schizophrenia, but many patients do not present adequate responsivity even to this …

The histamine H4 receptor (H4R) plays key role in immune cell function and is a highly
valued target for treating allergic and inflammatory diseases. However, structural information …

Objectives To assess the clinical efficacy of clozapine in bipolar disorder and its adverse
effect profile. Methods A literature search with no year and no language restriction was …

Schizophrenia is a severe mental disorder with a chronic, progressive course. The etiology
of this condition is linked to the interactions of multiple genes and environmental factors. The …