The genetic landscape of substance use disorders
Substance use disorders represent a significant public health concern with considerable
socioeconomic implications worldwide. Twin and family-based studies have long …
socioeconomic implications worldwide. Twin and family-based studies have long …
The broken Alzheimer's disease genome
The complex pathobiology of late-onset Alzheimer's disease (AD) poses significant
challenges to therapeutic and preventative interventions. Despite these difficulties …
challenges to therapeutic and preventative interventions. Despite these difficulties …
Incorporating genetic similarity of auxiliary samples into eGene identification under the transfer learning framework
Background The term eGene has been applied to define a gene whose expression level is
affected by at least one independent expression quantitative trait locus (eQTL). It is both …
affected by at least one independent expression quantitative trait locus (eQTL). It is both …
Identification of drug repurposing candidates for the treatment of anxiety: a genetic approach
Anxiety disorders are a group of prevalent and heritable neuropsychiatric diseases. We
previously conducted a genome-wide association study (GWAS) which identified genomic …
previously conducted a genome-wide association study (GWAS) which identified genomic …
How can we obtain truly translational mouse models to improve clinical outcomes in schizophrenia?
SJ Clapcote - Disease Models & Mechanisms, 2022 - journals.biologists.com
Schizophrenia is a serious mental illness affecting 0.7% of the world's population. Despite
over 50 years of schizophrenia drug identification and development, there have been no …
over 50 years of schizophrenia drug identification and development, there have been no …
Association of maternal and paternal personality disorders with risk of mental disorders in children: A nationwide, register‐based cohort study of 1,406,965 children
ICT Gjøde, TM Laursen, AD Müller… - Acta Psychiatrica …, 2024 - Wiley Online Library
Background Knowledge of the association between parental personality disorders and
mental disorders in children is limited. To examine the association between parental …
mental disorders in children is limited. To examine the association between parental …
[PDF][PDF] Reconstructing Psychopathology: A data-driven reorganization of the symptoms in DSM-5
In this study, we reduced the DSM-5 to its constituent symptoms and reorganized them
based on patterns of covariation in individuals'(n= 14,762) self-reported experiences of the …
based on patterns of covariation in individuals'(n= 14,762) self-reported experiences of the …
Biomarkers in Psychiatry: Conceptual and Methodological Challenges
There are fundamental differences in the diagnostic process and the pathogenesis/
pathophysiology of mental disorders compared to other clinical areas that pose a challenge …
pathophysiology of mental disorders compared to other clinical areas that pose a challenge …
Stratifying early‐onset emotional disorders: using genetics to assess persistence in young people of European and South Asian ancestry
Background Depression and anxiety are the most common mental health problems in young
people. Currently, clinicians are advised to wait before initiating treatment for young people …
people. Currently, clinicians are advised to wait before initiating treatment for young people …
Fallacies and Pitfalls in Genome-Wide Association Studies*
J Hecker, A Craig, A Hughes, J Neidich… - 2023 Guardians …, 2023 - ieeexplore.ieee.org
Since the first genome-wide association study (GWAS) identifying variants associated with
myocardial infarction was published over 20 years ago, GWASs have emerged as a …
myocardial infarction was published over 20 years ago, GWASs have emerged as a …