One of the exciting movements in microbial sciences has been a refocusing and
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …

All organisms produce specialized organic molecules, ranging from small volatile chemicals
to large gene-encoded peptides, that have evolved to provide them with diverse cellular and …

A variety of organisms, such as bacteria, fungi, and plants, produce secondary metabolites,
also known as natural products. Natural products have been a prolific source and an …

Terpenoids, critical components of human medicine, are the largest family of natural
products. Fungi are an important source of terpenoids, but many of the corresponding …

Genome mining of biosynthetic pathways with no identifiable core enzymes can lead to
discovery of the so-called unknown (biosynthetic route)–unknown (molecular structure) …

Societal Impact Statement Plants and fungi have provided, or inspired, key pharmaceuticals
for global health challenges, including cancer, heart disease, dementia, and malaria, and …

Covering: 2015 to the end of 2020 Fungal-derived polyketides, non-ribosomal peptides,
terpenoids and their hybrids contribute significantly to the chemical space of total natural …

Covering: 2002 to 2020 In their natural environment, fungi must compete for resources. It
has been hypothesized that this competition likely induces the biosynthesis of secondary …

Covering: 2010 to 2022 Heterologous expression of natural product biosynthetic gene
clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways …

Biosynthesis of the flavonoid naringenin in plants and bacteria is commonly catalysed by a
type III polyketide synthase (PKS) using one p-coumaroyl-CoA and three malonyl-CoA …