Fungi produce a wide diversity of secondary metabolites with interesting biological activities
for the health, industrial, and agricultural sectors. While fungal genomes have revealed an …

Fungi offer a deep source of natural products but remain underutilized. Most biosynthetic
gene clusters (BGCs) that can be detected are silent or “cryptic” in standard lab cultures and …

Lichens have been widely used in traditional medicine, especially by indigenous
communities worldwide. However, their slow growth and difficulties in the isolation of lichen …

Geranyl diphosphate (GPP) is a direct precursor in the biosynthesis of monoterpenes.
Previous studies focused on the manipulation of metabolic flux to improve GPP supply in …

Genome mining and bioinformatics analyses allowed us to rationally find a candidate
biosynthetic gene cluster for a new cyclic depsipeptide of Chaetomium mollipilium. A …

The ability of the yeast Saccharomyces cerevisiae to convert glucose, even in the presence
of oxygen, via glycolysis and the fermentative pathway to ethanol has played an important …

Through genome mining for fungal macrolide natural products, we discovered a
characteristic family of putative macrolide biosynthetic gene clusters that contain a …

Scarce research into the secondary metabolites of the fungi Pseudogymnoascus spp. has
shown a hidden biosynthetic potential for biologically active compounds. This work …

Since the discovery of penicillin, natural products and their derivatives have been a valuable
resource for drug discovery. With recent development of genome mining approaches in the …

Filamentous fungi such as species from the genus Fusarium are capable of producing a
wide palette of interesting metabolites relevant to health, agriculture and biotechnology …