Fluid transport in the brain
MK Rasmussen, H Mestre… - Physiological …, 2022 - journals.physiology.org
The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …
wakefulness, the brain is geared fully toward processing information and behaving, while …
The glymphatic system: a novel component of fundamental neurobiology
LM Hablitz, M Nedergaard - Journal of Neuroscience, 2021 - Soc Neuroscience
Throughout the body, lymphatic fluid movement supports critical functions including
clearance of excess fluid and metabolic waste. The glymphatic system is the analog of the …
clearance of excess fluid and metabolic waste. The glymphatic system is the analog of the …
[HTML][HTML] The glymphatic hypothesis: the theory and the evidence
SB Hladky, MA Barrand - Fluids and Barriers of the CNS, 2022 - Springer
The glymphatic hypothesis proposes a mechanism for extravascular transport into and out of
the brain of hydrophilic solutes unable to cross the blood–brain barrier. It suggests that there …
the brain of hydrophilic solutes unable to cross the blood–brain barrier. It suggests that there …
[HTML][HTML] Mechanisms of blood–brain barrier dysfunction in traumatic brain injury
A Cash, MH Theus - International journal of molecular sciences, 2020 - mdpi.com
Traumatic brain injuries (TBIs) account for the majority of injury-related deaths in the United
States with roughly two million TBIs occurring annually. Due to the spectrum of severity and …
States with roughly two million TBIs occurring annually. Due to the spectrum of severity and …
Current concepts in intracranial interstitial fluid transport and the glymphatic system: part II—imaging techniques and clinical applications
JM Klostranec, D Vucevic, KD Bhatia, HGJ Kortman… - Radiology, 2021 - pubs.rsna.org
The glymphatic system is a recently discovered network unique to the central nervous
system that allows for dynamic exchange of interstitial fluid (ISF) and cerebrospinal fluid …
system that allows for dynamic exchange of interstitial fluid (ISF) and cerebrospinal fluid …
Blood–brain barrier breakdown in relationship to Alzheimer and vascular disease
Objective Blood–brain barrier (BBB) breakdown has been suggested to be an early
biomarker in human cognitive impairment. However, the relationship between BBB …
biomarker in human cognitive impairment. However, the relationship between BBB …
Glymphatic imaging using MRI
T Taoka, S Naganawa - Journal of Magnetic Resonance …, 2020 - Wiley Online Library
In recent years, the existence of a mass transport system in the brain via cerebrospinal fluid
(CSF) or interstitial fluid (ISF) has been suggested by many studies. The glymphatic system …
(CSF) or interstitial fluid (ISF) has been suggested by many studies. The glymphatic system …
[HTML][HTML] In vivo methods for imaging blood–brain barrier function and dysfunction
WJ Harris, MC Asselin, R Hinz, LM Parkes… - European journal of …, 2023 - Springer
The blood–brain barrier (BBB) is the interface between the central nervous system and
systemic circulation. It tightly regulates what enters and is removed from the brain …
systemic circulation. It tightly regulates what enters and is removed from the brain …
[HTML][HTML] Non-invasive MRI of blood–cerebrospinal fluid barrier function
The blood–cerebrospinal fluid barrier (BCSFB) is a highly dynamic transport interface that
serves brain homeostasis. To date, however, understanding of its role in brain development …
serves brain homeostasis. To date, however, understanding of its role in brain development …
A clinical primer for the glymphatic system
LP Carlstrom, A Eltanahy, A Perry, AA Rabinstein… - Brain, 2022 - academic.oup.com
The complex and dynamic system of fluid flow through the perivascular and interstitial
spaces of the CNS has new-found implications for neurological diseases. CSF movement …
spaces of the CNS has new-found implications for neurological diseases. CSF movement …