Altered metabolism in tumor cells has been a focus of cancer research for as long as a
century but has remained controversial and vague due to an inhomogeneous overall …

Abstract Overexpressed Solute Carrier Family 16 Member 3 (SLC16A3, also called MCT4)
plays a critical role in hypoxic cancer cell growth and proliferation, by expelling glycolysis …

From attributing mutations to cancers with the advent of cutting-edge genetic technology in
recent decades, to re-searching the age-old theory of intrinsic metabolic shift of cancers …

Simple Summary Tumors exhibit metabolic changes that differentiate them from the normal
tissues from which they derive. These metabolic changes favor tumor growth, are primarily …

Head and neck squamous cell carcinoma (HNSCC) is comprised of metabolically linked
distinct compartments. Cancer-associated fibroblasts (CAF) and nonproliferative carcinoma …

Mammography is an important screening modality for the early detection of DCIS and breast
cancer lesions. More specifically, high mammographic density is associated with an …

The IKK/nuclear factor-kappaB pathway (NF-κB) is critical in proper immune function, cell
survival, apoptosis, cellular proliferation, synaptic plasticity, and even memory. While NF-κB …

Tumour proliferation is promoted by an intratumoral metabolic symbiosis in which lactate
from stromal cells fuels energy generation in the oxygenated domain of the tumour …

Background Cancer-associated fibroblasts (CAFs) represent the predominant stromal
component within the tumour microenvironment (TME), exhibiting considerable …

N-acetylcysteine (NAC) has been used as an antioxidant drug in tumor cells and preclinical
mice tumor xenografts, and it improves adaptive immunotherapy in melanoma. NAC is not …