Reciprocal interactions between neoplastic cells and their microenvironment are crucial
events in carcinogenesis and tumor progression. Pervasive stromal reprogramming and …

HIV-1 infection leads to a depletion of CD4 T-cells associated with a persistent immune
inflammation and changes in cellular metabolism. Most effort of managing HIV infection with …

Previous studies have shown that melatonin can mitigate cryopreservation-induced
mitochondrial dysfunction in oocytes; however, the underlying molecular mechanism …

Metabolic dysregulation within the tumor microenvironment (TME) is critical to the process of
tumorigenesis in various cancer types. Thyrocyte metabolism in papillary and anaplastic …

The most common cancers of the aerodigestive tract (ADT) are non-small cell lung cancer
(NSCLC) and head and neck squamous cell carcinoma (HNSCC). The tumor stroma plays …

Radiotherapy plays a key role in the management of lung cancer patients in curative and
palliative settings. Traditionally, radiotherapy was either given alone or in combination with …

Although the role of autophagy has been implicated in several forms of chronic hepatitis, it is
still not fully understood. Active autophagy eliminates damaged molecules and organelles …

The assumption that chemical and radiation induced cancers act in a manner that is additive
to background was proposed in the mid-1970s. It was adopted by the US Environmental …

Purpose Ovarian cancer is the most lethal gynecologic malignancy. Resistance to platinum-
based chemotherapy affects the overall survival of patients. This study used an integrated …

Objectives/Hypothesis In many cancers, varying regions within the tumor are often
phenotypically heterogeneous, including their metabolic phenotype. Further, tumor regions …