The worldwide obesity pandemic requires the use of antiobesity drugs. Sibutramine is an
anti-obesity drug that has been used worldwide but is indiscriminately consumed in Brazil …

20 世纪20 年代, 德国生化学家瓦伯格发现即使在有氧条件下, 肿瘤细胞也是通过糖酵解的方式
获得生存必需的能量, 这一现象被称为瓦伯格效应. 然而, 后续越来越多的研究发现并非所有的 …

Abstract 'The Warburg effect'is one of the aberrant glucose metabolism pathways in cancer
cells that generate malignant phenotypes and promotes cancer progression. However, in …

Head and neck squamous cell carcinoma (HNSCC) is the 7 th leading cancer worldwide
with 470,000 deaths per year. Cigarette smoking is the main cause of the disease. Standard …

Breast cancer remains the second most prevalent cancer among women in the US with
metastatic breast cancer having the worst prognosis. A rapidly proliferating tumor under …

肿瘤微环境(TME) 在局部耐药性, 免疫逃脱和远端转移等多个肿瘤发生, 发展的步骤中起关键
作用. 依据不同个体的TME, 准确评估和选择临床用药, 可有效控制原位癌和转移癌的恶性转化 …

Evo-devo has been shaped by a myriad of natural forces, such as environmental factors,
opportunism, survival of the fittest and even disease, including cancer. The influence of the …

Résumé Le sarcome de Ewing est la seconde tumeur pédiatrique de l'os la plus fréquente.
Elle est caractérisée par une translocation chromosomique résultant à la fusion de EWSR1 …

The primary goal of my research project is to develop novel drug candidates that target
cancer cell glycolysis and oxidative phosphorylation via MCT1 and/or MCT4 inhibition for …

Our understanding of human biology and disease is based on the last millennia's gain of
knowledge, which has been exponentially accelerated since the invention of optical and" …