Many populations suffer from thrombotic disorders such as stroke, myocardial infarction,
unstable angina and thromboembolic disease. Thrombus is one of the major threatening …

Sulfamide compounds are an important class of motif in various applications in
pharmaceutical agents, agriculture, and material science. In this review, various synthetic …

The use of drugs derived from benzothiadiazine, a bicyclic heterocyclic benzene derivative,
has become a widespread treatment for diseases such as hypertension, low blood sugar or …

Palladium-catalyzed N-allylation of anthranilic acids 1a–j with allyl alcohol 2a in the
presence of Pd (OAc) 2, sodium diphenylphosphinobenzene-3-sulfonate (TPPMS) in THF …

Thromboembolic diseases are the leading causes of morbidity and mortality in the
developed world. Anticoagulants provide effective treatment for venous or arterial …

Coronary heart disease (CHD) is the leading cause of mortality and morbidity in the United
States. Currently, there are approximately 12 million Americans with CHD, which is most …

The sulfamide functional group has been extensively employed in organic synthesis to
discover probes and drugs in various applications such as cancer, human …

Starting from commercially available 4-phenylbutanoic acids, a series of novel sulfamides
were synthesized and investigated for their inhibition properties on the human carbonic …

Introduction: Thrombosis is a common causal pathology for stroke, acute coronary syndrome
and venous thromboembolism disorders, which are the leading cause of death worldwide …

Factor Xa is a serine protease that has a critical role in the blood coagulation cascade by
ultimately regulating the production of thrombin. There is now ample evidence for the role of …