Maternal metabolic adaptations during pregnancy ensure appropriate nutrient supply to the
developing fetus. This is facilitated by reductions in maternal peripheral insulin sensitivity …

Type 1 Diabetes (T1D) is a chronic autoimmune disease characterized by a gradual
destruction of insulin-producing β-cells in the endocrine pancreas due to innate and specific …

Pancreatic β-cell mass expands during pregnancy and regresses in the postpartum period
in conjunction with dynamic metabolic demands on maternal glucose homeostasis. To …

The birth rates among women of advanced maternal age (AMA) have risen over the last two
decades; yet, pregnancies with AMA are considered high-risk and are associated with a …

Pancreatic islets, particularly insulin-producing β-cells, are central regulators of glucose
homeostasis capable of responding to a variety of metabolic stressors. Pregnancy is a …

Diabetic foot disease (DFD) is a common and serious complication for diabetes and is
characterized with impaired angiogenesis. In addition to the well-defined role of vascular …

Aim To show that depletion of pancreatic macrophages impairs gestational beta cell
proliferation and leads to glucose intolerance. Materials and Methods Genetic animal …

Spinal fusion is an effective treatment for low back pain and typically applied with prosthetic
fixation devices. Spinal fusion can be improved by transplantation of mesenchymal stem …

Gestational diabetes mellitus (GDM) is a significant pregnancy complication linked to
perinatal complications and an elevated risk of future metabolic disorders for both mothers …

Clinical evidence suggests that patients with chronic pancreatitis (CP) are prone to
development of diabetes (chronic pancreatitis-related diabetes; CPRD), whereas the …