Interactions between the developing microbiome and maturing immune system in early life
are critical for establishment of a homeostasis beneficial to both host and commensals. The …

Airway epithelium forms a physical barrier that protects the lung from the entrance of inhaled
allergens, irritants, or microorganisms. This epithelial structure is maintained by tight …

Cystic fibrosis is a hereditary disease that mainly affects secretory organs in humans. It is
caused by mutations in the gene encoding CFTR with the most common phenylalanine …

Chronic inflammatory pulmonary diseases are characterized by recurrent and persistent
inflammation of the airways, commonly associated with poor clinical outcomes. Although …

Defects of the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) protein
affect the homeostasis of chloride, bicarbonate, sodium, and water in the airway surface …

Simple Summary Cystic fibrosis (CF) is a genetic condition that affects the lungs, digestion,
and other body systems. People with CF have a higher chance of developing certain types …

Defective CFTR biogenesis and activity in cystic fibrosis airways leads to airway dehydration
and impaired mucociliary clearance, resulting in chronic airway infection and inflammation …

Neutrophils, a key innate immune component, are powerful effector leukocytes for mediating
opposing effects on tumor progression and ameliorating pathogen infections. However, their …

The global burden of respiratory diseases is very high and still on the rise, prompting the
need for accurate models for basic and translational research. Several model systems are …

Ventilatory support, such as supplemental oxygen, used to save premature infants impairs
the growth of the pulmonary microvasculature and distal alveoli, leading to …