Asymmetric organocatalysis: an enabling technology for medicinal chemistry

B Han, XH He, YQ Liu, G He, C Peng… - Chemical Society Reviews, 2021 - pubs.rsc.org
The efficacy and synthetic versatility of asymmetric organocatalysis have contributed
enormously to the field of organic synthesis since the early 2000s. As asymmetric …

Catalytic C–C bond-forming multi-component cascade or domino reactions: Pushing the boundaries of complexity in asymmetric organocatalysis

CMR Volla, I Atodiresei, M Rueping - Chemical Reviews, 2014 - ACS Publications
The construction of carbon− carbon bonds, along with the creation of stereogenic carbon
centers, continues to be an appealing and demanding area of research, and processes in …

Stereocontrolled domino reactions

H Pellissier - Chemical Reviews, 2013 - ACS Publications
A domino reaction has been defined by Tietze as a reaction involving two or more bond-
forming transformations that take place under the same reaction conditions, without adding …

Asymmetric organocatalytic cyclization and cycloaddition reactions

A Moyano, R Rios - Chemical Reviews, 2011 - ACS Publications
The stereocontrolled construction of chiral carbo-and heterocycles is a topic of paramount
importance in modern organic synthesis, driven by the predominance of chiral mono-and …

Recent advances in organocatalytic methods for the synthesis of disubstituted 2-and 3-indolinones

R Dalpozzo, G Bartoli, G Bencivenni - Chemical Society Reviews, 2012 - pubs.rsc.org
In recent years, organocatalysis has enhanced its importance as a tool for the synthesis of
enantiomerically enriched compounds. Among the candidates for organocatalysis, the …

The diarylprolinol silyl ethers: ten years after

BS Donslund, TK Johansen, PH Poulsen… - Angewandte Chemie …, 2015 - Wiley Online Library
Asymmetric organocatalysis has experienced an incredible development since the
beginning of this century. The expansion of the field has led to a large number of efficient …

Applications of asymmetric organocatalysis in medicinal chemistry

J Alemán, S Cabrera - Chemical Society Reviews, 2013 - pubs.rsc.org
In the last decade, organocatalysis, the use of small chiral organic molecules as catalysts,
has proven to be a valuable and attractive tool for the synthesis of enantiomerically enriched …

Organocatalytic carbon–sulfur bond-forming reactions

P Chauhan, S Mahajan, D Enders - Chemical reviews, 2014 - ACS Publications
Carbon− heteroatom bond formations are very important reactions in organic synthesis and
have attracted the interest of many synthetic organic chemists, leading them to develop new …

Recent developments in asymmetric organocatalytic domino reactions

H Pellissier - Advanced Synthesis & Catalysis, 2012 - Wiley Online Library
Since about the year 2000, the research area of asymmetric organocatalysis has grown
rapidly to become one of the most fascinating and current fields in organic chemistry. In the …

Recent applications of thiourea-based organocatalysts in asymmetric multicomponent reactions (AMCRs)

T Parvin, R Yadav, LH Choudhury - Organic & biomolecular chemistry, 2020 - pubs.rsc.org
One-pot multiple bond-forming reactions under metal-free conditions have tremendous
potential in organic and medicinal chemistry considering their synthetic efficiency and eco …