Abstract The small GTPase RhoA and its downstream effectors are critical regulators in the
pathophysiological processes of asthma. The underlying mechanism, however, remains …

When olfactory receptor neurons respond to odours, a depolarizing Cl− efflux is a
substantial part of the response. This requires that the resting neuron accumulate Cl …

Both 17 beta-estradiol and prolactin play important roles in the mammary gland, raising the
possibility of functional cross-talk between the two signaling pathways. Here, we …

Mutations in gap junction proteins encoding beta connexions are believed to be a major
cause for congenital hearing loss. The purpose of this study was to do comparative analyses …

Abstract Background/Aims: Pendrin is a Cl-/I-/HCO3-exchanger playing a fundamental role
in controlling blood pressure and airway function, therefore representing an attractive target …

Malfunction of the SLC26A4 protein leads to Pendred syndrome, characterized by
sensorineural hearing loss, often associated with mild thyroid dysfunction and goiter. It is …

Background: Pendrin is a transport protein exchanging chloride for other anions, such as
iodide in the thyroid gland or bicarbonate in the inner ear. Mutations in the SLC26A4 gene …

Abstract SLC26A4/PDS mutations cause Pendred Syndrome and non-syndromic deafness.
but some aspects of function and regulation of the SLC26A4 polypeptide gene product …

Patients with PS or non-syndromic deafness were submitted to genetic/functional analyzes
of SLC26A4, of its binding domain for FOXI1 (FOXI1-DBD), of the transcription activator …

Objective Pendred syndrome (PS) is characterized by the association of sensorineural
hearing loss (SNHL) and a partial iodide organification defect at the thyroid level. It is …