Synapses between neurons are malleable biochemical structures, strengthening and
diminishing over time dependent on the type of information they receive. This phenomenon …

Genetic studies have demonstrated that conditional ablation of core autophagy genes in the
neural lineage leads to progressive neurodegeneration, indicating that this catabolic …

Over 25 years ago, a seminal paper demonstrated that the ubiquitin-proteasome system
(UPS) was involved in activity-dependent synaptic plasticity. Interest in this topic began to …

Protein degradation has many critical functions in the nervous system such as refinement of
synaptic connections during development and synaptic plasticity and memory in the adult …

Cellular resources must be reorganized for long-term synaptic plasticity during brain
information processing, in which coordinated gene transcription and protein turnover are …

Dynamic changes in synaptic strength rely on de novo protein synthesis and protein
degradation by the ubiquitin proteasome system (UPS). Disruption of either of these cellular …

One of the most intriguing features of the brain is its ability to be malleable, allowing it to
adapt continually to changes in the environment. Specific neuronal activity patterns drive …

The earth land area is heterogeneous in terms of elevation; about 45% of its land area
belongs to higher elevation with altitude above 500 meters compared to sea level. In most …

Over the last 20 years, a number of studies have provided strong support for protein
degradation mediated by the ubiquitin-proteasome system in synaptic plasticity and memory …

Proteasome activity at the excitatory synapse plays an important role in neuronal
communication. The proteasome translocation to synapses is mediated by neuronal activity …