Long‐term plasticity in the hippocampus: maintaining within and 'tagging'between synapses
Synapses between neurons are malleable biochemical structures, strengthening and
diminishing over time dependent on the type of information they receive. This phenomenon …
diminishing over time dependent on the type of information they receive. This phenomenon …
Regulation and roles of autophagy at synapses
V Nikoletopoulou, N Tavernarakis - Trends in cell biology, 2018 - cell.com
Genetic studies have demonstrated that conditional ablation of core autophagy genes in the
neural lineage leads to progressive neurodegeneration, indicating that this catabolic …
neural lineage leads to progressive neurodegeneration, indicating that this catabolic …
The ubiquitin-proteasome system and learning-dependent synaptic plasticity–A 10 year update
Over 25 years ago, a seminal paper demonstrated that the ubiquitin-proteasome system
(UPS) was involved in activity-dependent synaptic plasticity. Interest in this topic began to …
(UPS) was involved in activity-dependent synaptic plasticity. Interest in this topic began to …
Proteolysis, synaptic plasticity and memory
AN Hegde - Neurobiology of learning and memory, 2017 - Elsevier
Protein degradation has many critical functions in the nervous system such as refinement of
synaptic connections during development and synaptic plasticity and memory in the adult …
synaptic connections during development and synaptic plasticity and memory in the adult …
[HTML][HTML] Neuronal activity recruits the CRTC1/CREB axis to drive transcription-dependent autophagy for maintaining late-phase LTD
Y Pan, X He, C Li, Y Li, W Li, H Zhang, Y Wang, G Zhou… - Cell Reports, 2021 - cell.com
Cellular resources must be reorganized for long-term synaptic plasticity during brain
information processing, in which coordinated gene transcription and protein turnover are …
information processing, in which coordinated gene transcription and protein turnover are …
Perturbed proteostasis in autism spectrum disorders
SR Louros, EK Osterweil - Journal of neurochemistry, 2016 - Wiley Online Library
Dynamic changes in synaptic strength rely on de novo protein synthesis and protein
degradation by the ubiquitin proteasome system (UPS). Disruption of either of these cellular …
degradation by the ubiquitin proteasome system (UPS). Disruption of either of these cellular …
The malleable brain: plasticity of neural circuits and behavior–a review from students to students
N Schaefer, C Rotermund, EM Blumrich… - Journal of …, 2017 - Wiley Online Library
One of the most intriguing features of the brain is its ability to be malleable, allowing it to
adapt continually to changes in the environment. Specific neuronal activity patterns drive …
adapt continually to changes in the environment. Specific neuronal activity patterns drive …
Insight into the Effects of High‐Altitude Hypoxic Exposure on Learning and Memory
Z Zhang, Y Sun, Z Yuan, L Wang… - Oxidative Medicine …, 2022 - Wiley Online Library
The earth land area is heterogeneous in terms of elevation; about 45% of its land area
belongs to higher elevation with altitude above 500 meters compared to sea level. In most …
belongs to higher elevation with altitude above 500 meters compared to sea level. In most …
The diversity of linkage-specific polyubiquitin chains and their role in synaptic plasticity and memory formation
M Musaus, S Navabpour, TJ Jarome - Neurobiology of learning and …, 2020 - Elsevier
Over the last 20 years, a number of studies have provided strong support for protein
degradation mediated by the ubiquitin-proteasome system in synaptic plasticity and memory …
degradation mediated by the ubiquitin-proteasome system in synaptic plasticity and memory …
Interplay between NMDA receptor dynamics and the synaptic proteasome
JS Ferreira, B Kellermayer… - European Journal of …, 2021 - Wiley Online Library
Proteasome activity at the excitatory synapse plays an important role in neuronal
communication. The proteasome translocation to synapses is mediated by neuronal activity …
communication. The proteasome translocation to synapses is mediated by neuronal activity …