A major goal of cancer genomics is to identify all genes that play critical roles in
carcinogenesis. Most approaches focused on genes positively selected for mutations that …

The global impact of somatic structural variants (SVs) on gene regulation in advanced
tumors with complex treatment histories has been mostly uncharacterized. Here, using …

Abstract tRNA gene transcription by RNA polymerase III (Pol III) is a tightly regulated
process, but dysregulated Pol III transcription is widely observed in cancers. Approximately …

Prostate cancer is a prevalent cancer in men and consists of both indolent and aggressive
phenotypes. While active surveillance is recommended for the former, current treatments for …

Noncoding regulatory elements control gene expression and govern all biological
processes. Epigenomic profiling assays have identified millions of putative regulatory …

Simple Summary B-cell malignancies are a heterogenous group of lymphomas and
leukemias and are the 6th most common cancer-related cause of death. Apart from several …

Cancer is a leading cause of death worldwide. Sex influences cancer in a bewildering
variety of ways. In some cancer types, it affects prevalence; in others, genomic profiles …

The costs of developing, validating and buying new drugs are dramatically increasing. On
the other hand, sobering economies have difficulties in sustaining their healthcare systems …

The pathogenesis of cutaneous T‐cell lymphomas is not clear. In recent years, the genetic
changes in CTCL were explored. The detected mutations showed a great deal of …

Cancer cells exhibit rewired transcriptional regulatory networks that promote tumor growth
and survival. However, the mechanisms underlying the formation of these pathological …