Use of signals of positive and negative selection to distinguish cancer genes and passenger genes
L Bányai, M Trexler, K Kerekes, O Csuka, L Patthy - Elife, 2021 - elifesciences.org
A major goal of cancer genomics is to identify all genes that play critical roles in
carcinogenesis. Most approaches focused on genes positively selected for mutations that …
carcinogenesis. Most approaches focused on genes positively selected for mutations that …
Rearrangement-mediated cis-regulatory alterations in advanced patient tumors reveal interactions with therapy
Y Zhang, F Chen, E Pleasance, L Williamson… - Cell reports, 2021 - cell.com
The global impact of somatic structural variants (SVs) on gene regulation in advanced
tumors with complex treatment histories has been mostly uncharacterized. Here, using …
tumors with complex treatment histories has been mostly uncharacterized. Here, using …
[HTML][HTML] Widespread association of ERα with RMRP and tRNA genes in MCF-7 cells and breast cancers
JR Malcolm, NK Leese, PI Lamond-Warner… - Gene, 2022 - Elsevier
Abstract tRNA gene transcription by RNA polymerase III (Pol III) is a tightly regulated
process, but dysregulated Pol III transcription is widely observed in cancers. Approximately …
process, but dysregulated Pol III transcription is widely observed in cancers. Approximately …
[HTML][HTML] Immunotherapy of prostate cancer using novel synthetic DNA vaccines targeting multiple tumor antigens
D Bordoloi, P Xiao, H Choi, M Ho… - Genes & …, 2021 - ncbi.nlm.nih.gov
Prostate cancer is a prevalent cancer in men and consists of both indolent and aggressive
phenotypes. While active surveillance is recommended for the former, current treatments for …
phenotypes. While active surveillance is recommended for the former, current treatments for …
Genome-wide annotation of gene regulatory elements linked to cell fitness
Noncoding regulatory elements control gene expression and govern all biological
processes. Epigenomic profiling assays have identified millions of putative regulatory …
processes. Epigenomic profiling assays have identified millions of putative regulatory …
Enhancing B-Cell Malignancies—On Repurposing Enhancer Activity towards Cancer
Simple Summary B-cell malignancies are a heterogenous group of lymphomas and
leukemias and are the 6th most common cancer-related cause of death. Apart from several …
leukemias and are the 6th most common cancer-related cause of death. Apart from several …
Sex differences in cancer genomes: much learned, more unknown
C Zhu, PC Boutros - Endocrinology, 2021 - academic.oup.com
Cancer is a leading cause of death worldwide. Sex influences cancer in a bewildering
variety of ways. In some cancer types, it affects prevalence; in others, genomic profiles …
variety of ways. In some cancer types, it affects prevalence; in others, genomic profiles …
Drug repurposing in oncology, an attractive opportunity for novel combinatorial regimens
P Falvo, S Orecchioni, S Roma… - Current Medicinal …, 2021 - ingentaconnect.com
The costs of developing, validating and buying new drugs are dramatically increasing. On
the other hand, sobering economies have difficulties in sustaining their healthcare systems …
the other hand, sobering economies have difficulties in sustaining their healthcare systems …
Molecular pathogenesis of cutaneous lymphoma–Future directions
R Stadler, C Hain, C Cieslak… - Experimental …, 2020 - Wiley Online Library
The pathogenesis of cutaneous T‐cell lymphomas is not clear. In recent years, the genetic
changes in CTCL were explored. The detected mutations showed a great deal of …
changes in CTCL were explored. The detected mutations showed a great deal of …
Endogenous retroviruses mediate transcriptional rewiring in response to oncogenic signaling in colorectal cancer
A Ivancevic, DM Simpson, OM Joyner, SM Bagby… - Science …, 2024 - science.org
Cancer cells exhibit rewired transcriptional regulatory networks that promote tumor growth
and survival. However, the mechanisms underlying the formation of these pathological …
and survival. However, the mechanisms underlying the formation of these pathological …