This article presents a formula for modeling the lifetime incidence of cancer in humans. The
formula utilizes a Poisson distribution-based “np” model to predict cancer incidence, with “n” …

Fucosylation is one of the most important types of glycosylation in cancer. The expression
levels of fucosylated glycans generally increase during cancer development. Consequently …

DNA mismatch repair deficiency (MMRD) is caused by the inactivation of the mismatch
repair pathway, which corrects DNA replication-associated errors. MMRD results in an …

Exploring how genetic architecture shapes complex traits and diseases is a central premise
of human genetics. Over the years, genome-wide association studies (GWAS) have enabled …

Under normal conditions, cells of almost all tissues types express the same predominant
canonical transcript isoform at each gene locus. In cancer, however, splicing regulation is …

Deciphering mutational signatures provides insight into the causes and consequences of
somatic mutagenesis in normal tissues and tumours. Mutational signature analysis has …

Uterine leiomyomas (ULs) are extremely common, benign smooth muscle tumors. Their
incidence is 70% in the Caucasian population by the age of fifty and even higher in black …

B-cell lymphomas and leukemias derive from B cells at various stages of maturation and are
the 6th most common cancer-related cause of death. While the role of several oncogenes …

MicroRNA Buffering of Gene Duplications and Aneuploidy Page 1 MicroRNA Buffering of
Gene Duplications and Aneuploidy A thesis submitted to the University of Manchester for …