Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

Increasing evidence from epidemiological, clinical and experimental studies indicate that
age-related cerebromicrovascular dysfunction and microcirculatory damage play critical …

Maintenance of brain function depends on a constant blood supply. Deficits in cerebral
blood flow are linked to cognitive decline, and they have detrimental effects on the outcome …

Despite ongoing advances in stroke imaging and treatment, ischemic and hemorrhagic
stroke continue to debilitate patients with devastating outcomes at both the personal and …

The increasing prevalence of multifocal cerebral microhemorrhages (CMHs, also known as
“cerebral microbleeds”) is a significant, newly recognized problem in the aging population of …

Short-term regulation of cerebral blood flow (CBF) is controlled by myogenic, metabolic and
neurogenic mechanisms, which maintain flow within narrow limits, despite large changes in …

Transcranial Doppler ultrasound (TCD) can measure cerebral blood flow velocity in the main
intracranial vessels non-invasively and with high accuracy. Combined with the availability of …

SUMMARY 1 Blood pressure and organ perfusion are controlled by a variety of
cardiovascular control systems, such as the baroreceptor reflex and the renin–angiotensin …

Impaired cerebral autoregulation (CA) in moderate/severe traumatic brain injury (TBI) has
been identified as a strong associate with poor long-term outcomes, with recent data …

The myogenic response of small arteries and arterioles has been shown to contribute
significantly to autoregulation in different vascular beds. It is characterized by a constriction …