Non-coding RNAs in disease: from mechanisms to therapeutics
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are
not translated into proteins. Since their discovery, ncRNAs have emerged as important …
not translated into proteins. Since their discovery, ncRNAs have emerged as important …
MicroRNAs as therapeutic targets in cardiovascular disease
B Laggerbauer, S Engelhardt - The Journal of clinical …, 2022 - Am Soc Clin Investig
The discovery of microRNAs and their role in diseases was a breakthrough that inspired
research into microRNAs as drug targets. Cardiovascular diseases are an area in which …
research into microRNAs as drug targets. Cardiovascular diseases are an area in which …
Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology
The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
RNA-based therapeutics: from antisense oligonucleotides to miRNAs
S Bajan, G Hutvagner - Cells, 2020 - mdpi.com
The first therapeutic nucleic acid, a DNA oligonucleotide, was approved for clinical use in
1998. Twenty years later, in 2018, the first therapeutic RNA-based oligonucleotide was …
1998. Twenty years later, in 2018, the first therapeutic RNA-based oligonucleotide was …
The novel regulatory role of lnc RNA‐mi RNA‐mRNA axis in cardiovascular diseases
Y Huang - Journal of cellular and molecular medicine, 2018 - Wiley Online Library
Long noncoding RNA s (lnc RNA s) are RNA s longer than 200 nt in length that are
characterized by low levels of sequence conservation and expression; lnc RNA s modulate …
characterized by low levels of sequence conservation and expression; lnc RNA s modulate …
Endogenous microRNA sponges: evidence and controversy
DW Thomson, ME Dinger - Nature Reviews Genetics, 2016 - nature.com
The competitive endogenous RNA (ceRNA) hypothesis proposes that transcripts with
shared microRNA (miRNA) binding sites compete for post-transcriptional control. This …
shared microRNA (miRNA) binding sites compete for post-transcriptional control. This …
Cardiac fibrosis in myocardial infarction—from repair and remodeling to regeneration
V Talman, H Ruskoaho - Cell and tissue research, 2016 - Springer
Ischemic cell death during a myocardial infarction leads to a multiphase reparative response
in which the damaged tissue is replaced with a fibrotic scar produced by fibroblasts and …
in which the damaged tissue is replaced with a fibrotic scar produced by fibroblasts and …
Roles, functions, and mechanisms of long non-coding RNAs in cancer
Y Fang, MJ Fullwood - Genomics, Proteomics and …, 2016 - academic.oup.com
Long non-coding RNAs (lncRNAs) play important roles in cancer. They are involved in
chromatin remodeling, as well as transcriptional and post-transcriptional regulation, through …
chromatin remodeling, as well as transcriptional and post-transcriptional regulation, through …
Mechanistic pathways of sex differences in cardiovascular disease
V Regitz-Zagrosek, G Kararigas - Physiological reviews, 2016 - journals.physiology.org
Major differences between men and women exist in epidemiology, manifestation,
pathophysiology, treatment, and outcome of cardiovascular diseases (CVD), such as …
pathophysiology, treatment, and outcome of cardiovascular diseases (CVD), such as …
A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223
K Wang, BO Long, F Liu, JX Wang, CY Liu… - European heart …, 2016 - academic.oup.com
Aims Sustained cardiac hypertrophy accompanied by maladaptive cardiac remodelling
represents an early event in the clinical course leading to heart failure. Maladaptive …
represents an early event in the clinical course leading to heart failure. Maladaptive …