Background Physical frailty and sarcopenia show extensive clinical similarities. Whether
biomarkers exist that are shared by the two conditions is presently unclear. Methods We …

Sarcopenia, a geriatric disease characterized by a progressive loss of skeletal muscle mass
and loss of muscle function, constitutes a rising, often undiagnosed health problem. Its …

Most older individuals develop inflammageing, a condition characterized by elevated levels
of blood inflammatory markers that carries high susceptibility to chronic morbidity, disability …

Sarcopenia is an aged-related syndrome that is progressive and can be accelerated by
other concomitant disease states. Sarcopenia, characterized by loss of skeletal muscle …

Functional status is considered the main determinant of healthy aging. Impairment in
skeletal muscle and the cardiovascular system, two interrelated systems, results in …

Background Frailty is a geriatric syndrome that diminishes the potential for functional
recovery after a transcatheter aortic valve replacement (TAVR) or surgical aortic valve …

Acute inflammation is a physiological response to injury or infection, with a cascade of steps
that ultimately lead to the recruitment of immune cells to clear invading pathogens and heal …

Healthy ageing can be defined as “the process of developing and maintaining the functional
ability that enables wellbeing in older age”. Functional ability (ie, the health-related attributes …

It is well documented that the rate of aging can be slowed, but it remains unclear to which
extent aging-associated conditions can be reversed. How the interface of immunity and …

Osteoarthritis (OA), is a major cause of severe joint pain, physical disability and quality of life
impairment in the aging population across the developed and developing world. Increased …