Mesenchymal stem cell-derived exosomes: applications in regenerative medicine

MD Hade, CN Suire, Z Suo - Cells, 2021 - mdpi.com
Exosomes are a type of extracellular vesicles, produced within multivesicular bodies, that
are then released into the extracellular space through a merging of the multivesicular body …

Exosomes from adipose‐derived stem cells and application to skin wound healing

Y An, S Lin, X Tan, S Zhu, F Nie, Y Zhen, L Gu… - Cell …, 2021 - Wiley Online Library
Skin wound healing is an intractable problem that represents an urgent clinical need. To
solve this problem, a large number of studies have focused on the use of exosomes (EXOs) …

GelMA/PEGDA microneedles patch loaded with HUVECs-derived exosomes and Tazarotene promote diabetic wound healing

M Yuan, K Liu, T Jiang, S Li, J Chen, Z Wu, W Li… - Journal of …, 2022 - Springer
Clinical work and research on diabetic wound repair remain challenging globally. Although
various conventional wound dressings have been continuously developed, the efficacy is …

Clinical applications of stem cell-derived exosomes

F Tan, X Li, Z Wang, J Li, K Shahzad… - Signal Transduction and …, 2024 - nature.com
Although stem cell-based therapy has demonstrated considerable potential to manage
certain diseases more successfully than conventional surgery, it nevertheless comes with …

Mesenchymal stem/stromal cell-derived exosomes for immunomodulatory therapeutics and skin regeneration

DH Ha, H Kim, J Lee, HH Kwon, GH Park, SH Yang… - Cells, 2020 - mdpi.com
Exosomes are nano-sized vesicles that serve as mediators for cell-to-cell communication.
With their unique nucleic acids, proteins, and lipids cargo compositions that reflect the …

Stem cell-derived exosomes: emerging therapeutic opportunities for wound healing

C Zhou, B Zhang, Y Yang, Q Jiang, T Li, J Gong… - Stem cell research & …, 2023 - Springer
Wound healing is a dynamic and highly sequential process involving a series of overlapping
spatial and temporal phases, including hemostasis, inflammation, proliferation, and tissue …

Efficient angiogenesis-based diabetic wound healing/skin reconstruction through bioactive antibacterial adhesive ultraviolet shielding nanodressing with exosome …

M Wang, C Wang, M Chen, Y Xi, W Cheng, C Mao… - ACS …, 2019 - ACS Publications
Diabetic wound healing and angiogenesis remain a worldwide challenge for both clinic and
research. The use of adipose stromal cell derived exosomes delivered by bioactive dressing …

Exosome‐guided phenotypic switch of M1 to M2 macrophages for cutaneous wound healing

H Kim, SY Wang, G Kwak, Y Yang, IC Kwon… - Advanced …, 2019 - Wiley Online Library
Macrophages (Mϕs) critically contribute to wound healing by coordinating inflammatory,
proliferative, and angiogenic processes. A proper switch from proinflammatory M1 to anti …

Hopes and limits of adipose-derived stem cells (ADSCs) and mesenchymal stem cells (MSCs) in wound healing

L Mazini, L Rochette, B Admou, S Amal… - International journal of …, 2020 - mdpi.com
Adipose tissue derived stem cells (ADSCs) are mesenchymal stem cells identified within
subcutaneous tissue at the base of the hair follicle (dermal papilla cells), in the dermal …

Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice

J Sanz-Ros, N Romero-García, C Mas-Bargues… - Science …, 2022 - science.org
Aging is associated with an increased risk of frailty, disability, and mortality. Strategies to
delay the degenerative changes associated with aging and frailty are particularly interesting …