It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …

Endothelial cells synthesize and release vasoactive mediators in response to various
neurohumoural substances (eg bradykinin or acetylcholine) and physical stimuli (eg cyclic …

The endothelium, although only a single layer of cells lining the vascular and lymphatic
systems, contributes in multiple ways to vascular homeostasis. Subsequent to the 1980 …

Skeletal muscle blood flow is closely coupled to metabolic demand, and its regulation is
believed to be mainly the result of the interplay of neural vasoconstrictor activity and locally …

Endothelial dysfunction has been implicated as a key factor in the development of a wide
range of cardiovascular diseases, but its definition and mechanisms vary greatly between …

The endothelium maintains vascular homeostasis through the release of active vasodilators.
Although nitric oxide (NO) is recognized as the primary factor at level of conduit arteries …

The nature of the vasodilator endothelium-derived hyperpolarizing factor (EDHF) is
controversial, putatively involving diffusible factors and/or electrotonic spread of …

Gap junction channels provide an enclosed conduit for direct exchanges of signalling
molecules, including ions and small metabolites between cells. This system of …

The endothelium is a critical regulator of vascular tone, and dysfunction of the endothelium
contributes to numerous cardiovascular pathologies. Recent studies suggest that apamin …

Diabetes is one of the most prevalent metabolic disorders and is estimated to affect 400
million of 4.4% of population worldwide in the next 20 year. In diabetes, risk to develop …