Cytochrome P450 pathways of arachidonic acid metabolism
DL Kroetz, DC Zeldin - Current opinion in lipidology, 2002 - journals.lww.com
Cytochrome P450s metabolize arachidonic acid to hydroxyeicosatetraenoic acids and
epoxyeicosatrienoic acids. These eicosanoids are formed in a tissue and cell-specific …
epoxyeicosatrienoic acids. These eicosanoids are formed in a tissue and cell-specific …
Spatial separation of endothelial small‐ and intermediate‐conductance calcium‐activated potassium channels (KCa) and connexins: possible relationship to …
SL Sandow, CB Neylon, MX Chen… - Journal of …, 2006 - Wiley Online Library
Activation of endothelial cell small‐(S) and intermediate‐(I) conductance calcium‐activated
potassium channels (KCa) and current or molecular transfer via myoendothelial gap …
potassium channels (KCa) and current or molecular transfer via myoendothelial gap …
Nitric oxide, atherosclerosis and the clinical relevance of endothelial dysfunction
TJ Anderson - The Role of Nitric Oxide in Heart Failure, 2004 - Springer
The endothelium plays a key role in vascular homeostasis through the release of a variety of
autocrine and paracrine substances, the best characterized being nitric oxide. A healthy …
autocrine and paracrine substances, the best characterized being nitric oxide. A healthy …
Acute DPP-4 inhibition modulates vascular tone through GLP-1 independent pathways
Z Shah, C Pineda, T Kampfrath, A Maiseyeu… - Vascular …, 2011 - Elsevier
Evidence from both clinical and experimental studies indicates that Di-peptidyl peptidase-IV
(DPP-4) inhibition may mediate favorable effects on the cardiovascular system. The …
(DPP-4) inhibition may mediate favorable effects on the cardiovascular system. The …
Mechanisms of endothelial dysfunction: clinical significance and preventive non-pharmacological therapeutic strategies
S Taddei, L Ghiadoni, A Virdis… - Current …, 2003 - ingentaconnect.com
Endothelium-derived NO is not only a potent vasodilator but also inhibits platelet
aggregation, vascular smooth muscle cell migration and proliferation, monocyte adhesion …
aggregation, vascular smooth muscle cell migration and proliferation, monocyte adhesion …
Hyperhomocysteinemia and endothelial dysfunction
ZJ Cheng, X Yang, H Wang - Current hypertension reviews, 2009 - ingentaconnect.com
Hyperhomocysteinemia (HHcy) is a significant and independent risk factor for
cardiovascular diseases. Endothelial dysfunction (ED) is the earliest indicator of …
cardiovascular diseases. Endothelial dysfunction (ED) is the earliest indicator of …
Detection of human CYP2C8, CYP2C9, and CYP2J2 in cardiovascular tissues
TC DeLozier, GE Kissling, SJ Coulter, D Dai… - Drug Metabolism and …, 2007 - ASPET
The cytochrome P450 (P450) enzymes CYP2C8, CYP2C9, and CYP2J2 metabolize
arachidonic acid to epoxyeicosatrienoic acids, which are known to be vital in regulation of …
arachidonic acid to epoxyeicosatrienoic acids, which are known to be vital in regulation of …
Regulation of endothelium-derived vasoactive autacoid production by hemodynamic forces
R Busse, I Fleming - Trends in pharmacological sciences, 2003 - cell.com
Endothelial cells, which are situated at the interface between blood and the vessel wall,
have a crucial role in controlling vascular tone and homeostasis, particularly in determining …
have a crucial role in controlling vascular tone and homeostasis, particularly in determining …
Endothelial potassium channels, endothelium‐dependent hyperpolarization and the regulation of vascular tone in health and disease
HA Coleman, M Tare… - Clinical and Experimental …, 2004 - Wiley Online Library
The elusive nature of endothelium‐derived hyperpolarizing factor (EDHF) has hampered
detailed study of the ionic mechanisms that underlie the EDHF hyperpolarization and …
detailed study of the ionic mechanisms that underlie the EDHF hyperpolarization and …
Endothelium-derived hyperpolarizing factor: a cousin to nitric oxide and prostacyclin
RM Bryan, J You, EM Golding… - The Journal of the …, 2005 - pubs.asahq.org
There is now strong evidence that an endothelial mechanism, other than nitric oxide or
prostacyclin, exists for dilating arteries and arterioles. This third pathway has been named …
prostacyclin, exists for dilating arteries and arterioles. This third pathway has been named …