Cytochrome P450s metabolize arachidonic acid to hydroxyeicosatetraenoic acids and
epoxyeicosatrienoic acids. These eicosanoids are formed in a tissue and cell-specific …

Activation of endothelial cell small‐(S) and intermediate‐(I) conductance calcium‐activated
potassium channels (KCa) and current or molecular transfer via myoendothelial gap …

The endothelium plays a key role in vascular homeostasis through the release of a variety of
autocrine and paracrine substances, the best characterized being nitric oxide. A healthy …

Evidence from both clinical and experimental studies indicates that Di-peptidyl peptidase-IV
(DPP-4) inhibition may mediate favorable effects on the cardiovascular system. The …

Endothelium-derived NO is not only a potent vasodilator but also inhibits platelet
aggregation, vascular smooth muscle cell migration and proliferation, monocyte adhesion …

Hyperhomocysteinemia (HHcy) is a significant and independent risk factor for
cardiovascular diseases. Endothelial dysfunction (ED) is the earliest indicator of …

The cytochrome P450 (P450) enzymes CYP2C8, CYP2C9, and CYP2J2 metabolize
arachidonic acid to epoxyeicosatrienoic acids, which are known to be vital in regulation of …

Endothelial cells, which are situated at the interface between blood and the vessel wall,
have a crucial role in controlling vascular tone and homeostasis, particularly in determining …

The elusive nature of endothelium‐derived hyperpolarizing factor (EDHF) has hampered
detailed study of the ionic mechanisms that underlie the EDHF hyperpolarization and …

There is now strong evidence that an endothelial mechanism, other than nitric oxide or
prostacyclin, exists for dilating arteries and arterioles. This third pathway has been named …