miRNAs role in bladder cancer pathogenesis and targeted therapy: Signaling pathways interplay–A review

HA El-Mahdy, EGE Elsakka, AA El-Husseiny… - … -Research and Practice, 2023 - Elsevier
Bladder cancer (BC) is the 11th most popular cancer in females and 4th in males. A lot of
efforts have been exerted to improve BC patients' care. Besides, new approaches have …

Hallmarks and biomarkers of skin senescence: An updated review of skin senotherapeutics

D Bulbiankova, R Díaz-Puertas, FJ Álvarez-Martínez… - Antioxidants, 2023 - mdpi.com
Aging is a complex process characterized by an ongoing decline in physiological functions,
leading to degenerative diseases and an increased probability of death. Cellular …

Explore the effect of the structure-activity relationship and dose-effect relationship on the antioxidant activity of licorice flavonoids

Y Hu, P Liang, Z Wang, CP Jiang, Q Zeng… - Journal of Molecular …, 2023 - Elsevier
Licorice flavonoids (LCF) are one of the homologous substances of medicine and food,
which have good antioxidant activity. However, the molecular mechanism affecting its …

Mitochondrial aging and senolytic natural products with protective potential

A Deledda, E Giordano, F Velluzzi, G Flore… - International journal of …, 2022 - mdpi.com
Living organisms do not disregard the laws of thermodynamics and must therefore consume
energy for their survival. In this way, cellular energy exchanges, which aim above all at the …

Single-cell and spatial RNA sequencing reveal the spatiotemporal trajectories of fruit senescence

X Li, B Li, S Gu, X Pang, P Mason, J Yuan, J Jia… - Nature …, 2024 - nature.com
The senescence of fruit is a complex physiological process, with various cell types within the
pericarp, making it highly challenging to elucidate their individual roles in fruit senescence …

Exosomal miR‐141‐3p from PDLSCs alleviates high glucose‐induced senescence of PDLSCs by activating the KEAP1‐NRF2 signaling pathway

M Liu, R Chen, Y Xu, J Zheng, M Wang… - Stem Cells …, 2023 - Wiley Online Library
Human periodontal ligament stem cells (PDLSCs) are the most promising stem cells for
periodontal tissue engineering. Senescent PDLSCs have diminished abilities to proliferate …

[HTML][HTML] The redox-responsive roles of intermediate filaments in cellular stress detection, integration and mitigation

D Pérez-Sala, RA Quinlan - Current Opinion in Cell Biology, 2024 - Elsevier
Intermediate filaments are critical for cell and tissue homeostasis and for stress responses.
Cytoplasmic intermediate filaments form versatile and dynamic assemblies that interconnect …

Crosstalk between oxidative stress and aging in neurodegeneration disorders

RF Abdelhamid, S Nagano - Cells, 2023 - mdpi.com
The world population is aging rapidly, and increasing lifespan exacerbates the burden of
age-related health issues. On the other hand, premature aging has begun to be a problem …

Rational Design of Multifunctional Ferulic Acid Derivatives Aimed for Alzheimer's and Parkinson's Diseases

EG Guzmán-López, M Reina, LF Hernández-Ayala… - Antioxidants, 2023 - mdpi.com
Ferulic acid has numerous beneficial effects on human health, which are frequently
attributed to its antioxidant behavior. In this report, many of them are reviewed, and 185 new …

Mitochondria pleiotropism in stem cell senescence: Mechanisms and therapeutic approaches

C Mas-Bargues - Free Radical Biology and Medicine, 2023 - Elsevier
Aging is a complex biological process characterized by a progressive decline in cellular and
tissue function, ultimately leading to organismal aging. Stem cells, with their regenerative …