Abstract Interleukin‐23 (IL‐23) is a heterodimeric cytokine belonging to the IL‐6/IL‐12 family
that plays a key role in several of autoimmune and inflammatory disorders. This family …

Chronic low-grade inflammation induced by obesity is a central risk factor for the
development of metabolic syndrome. High low-density lipoprotein cholesterol (LDL-c) …

Background Numerous cytokines are implicated in the immunopathogenesis of multiple
sclerosis (MS), but studies are often limited to whole blood (WB) or peripheral blood …

Until recently, autoimmune diseases had been categorized as either Th1-or Th2-mediated
diseases. However, the discovery of a novel subset of helper T cells producing interleukin …

Introduction Rheumatoid arthritis (RA) is considered a T cell driven autoimmune disease,
therefore, the ability of B cell depleting biologics, eg, anti-CD20 antibodies, to alleviate RA is …

Introduction The functional relevance of synovial ectopic lymphoid neogenesis (ELN) in
rheumatoid arthritis (RA) remains unknown. As ELN correlates with the degree of tissue …

Background Giant-cell arteritis (GCA) is considered a T helper (Th) 1-and Th17-mediated
disease. Interleukin (IL)-12 is a heterodimeric cytokine (p35/p40) involved in Th1 …

Abstract Toll‑like receptor 4 (TLR4) and the interleukin (IL)‑23/IL‑17A axis serve an important
role in tumor immunology. In the present study, the activation of the TLR4/myeloid …

Abstract Objective Interleukin-35 (IL-35) is a heterodimeric member of the IL-12 family
consisting of p35/IL-12a and EBI3/IL-27b subunits. Expressed in murine Treg cells, IL-35 …

Objective. A Th1 biased immune response in synovial fluid has been reported in children
with polyarticular and extended oligoarticular-type juvenile idiopathic arthritis (JIA). We …