The role of IL‐23 receptor signaling in inflammation‐mediated erosive autoimmune arthritis and bone remodeling
W Razawy, M van Driel… - European Journal of …, 2018 - Wiley Online Library
Abstract The IL‐23/Th17 axis has been implicated in the development of autoimmune
diseases, such as rheumatoid arthritis (RA) and psoriatic arthritis (PsA). RA and PsA are …
diseases, such as rheumatoid arthritis (RA) and psoriatic arthritis (PsA). RA and PsA are …
Interleukin-22 produced by alveolar macrophages during activation of the innate immune response
M Hansson, E Silverpil, A Lindén, P Glader - Inflammation Research, 2013 - Springer
Objective and design Interleukin (IL)-22 is important for mucosal host defense. Whereas
previous studies focus on lymphocytes as sources of IL-22, we determined whether IL-22 is …
previous studies focus on lymphocytes as sources of IL-22, we determined whether IL-22 is …
Dysregulated serum IL-23 and SIRT1 activity in peripheral blood mononuclear cells of patients with rheumatoid arthritis
D Wendling, W Abbas, M Godfrin-Valnet, A Kumar… - PloS one, 2015 - journals.plos.org
Sirtuin 1 (Sirt1) is a class III histone deacetylase (HDAC) that modulates gene expression
and is involved in the regulation of proinflammatory cytokines. Interleukin-23 (IL-23) is …
and is involved in the regulation of proinflammatory cytokines. Interleukin-23 (IL-23) is …
The role of IL-23/Th17 pathway in patients with primary immune thrombocytopenia
Background Primary immune thrombocytopenia (ITP) is an autoimmune bleeding disorder
with an unclear etiology. This study aims to investigate the role of IL-23/Th17 pathway in …
with an unclear etiology. This study aims to investigate the role of IL-23/Th17 pathway in …
Synoviocytes and skin fibroblasts show opposite effects on IL-23 production and IL-23 receptor expression during cell interactions with immune cells
M Noack, P Miossec - Arthritis Research & Therapy, 2022 - Springer
Abstract Background The IL-23/IL-17 axis is involved in inflammatory diseases including
arthritis and psoriasis. However, the response to IL-23 or IL-17 inhibitors is different …
arthritis and psoriasis. However, the response to IL-23 or IL-17 inhibitors is different …
Cytokine secretion by pathogen recognition receptor-stimulated dendritic cells in rheumatoid arthritis and ankylosing spondylitis
C Prevosto, JC Goodall, JSH Gaston - The Journal of rheumatology, 2012 - jrheum.org
Objective. Interleukin 23 (IL-23) plays a major role in differentiation and survival of IL-17-
secreting CD4+ Th17 cells. Having noted a higher frequency of Th17 cells in ankylosing …
secreting CD4+ Th17 cells. Having noted a higher frequency of Th17 cells in ankylosing …
Structural cell heterogeneity underlies the differential contribution of IL-17A, IL-17F and IL-23 to joint versus skin chronic inflammation
M Robert, P Miossec - Autoimmunity Reviews, 2024 - Elsevier
The current therapeutic strategy used in immune-mediated inflammatory diseases (IMIDs)
primarily targets immune cells or associated-pathways. However, recent evidence suggests …
primarily targets immune cells or associated-pathways. However, recent evidence suggests …
Investigating the role of the interleukin-23/-17A axis in rheumatoid arthritis
P Hillyer, MJ Larche, EP Bowman… - …, 2009 - academic.oup.com
Objective. IL-23 is a pro-inflammatory cytokine proposed to be central to the development of
autoimmune disease. We investigated whether IL-23, together with the downstream …
autoimmune disease. We investigated whether IL-23, together with the downstream …
Interleukin-23 Involved in Fibrotic Autoimmune Diseases: New Discoveries
Interleukin (IL)-23 is a central pro-inflammatory cytokine with a broad range of effects on
immune responses. IL-23 is pathologically linked to the induction of the production of the pro …
immune responses. IL-23 is pathologically linked to the induction of the production of the pro …
[HTML][HTML] The potential role of Th17 in mediating the transition from acute to chronic autoimmune inflammation: rheumatoid arthritis as a model
G Ferraccioli, G Zizzo - Discovery medicine, 2011 - discoverymedicine.com
T helper 17 cells (Th17) have arisen in the last 15 years as major effector cells in several
chronic inflammatory states. In synovitis associated with rheumatoid arthritis (RA), Th17 …
chronic inflammatory states. In synovitis associated with rheumatoid arthritis (RA), Th17 …