Allergen-specific IgE plays an essential role in the pathogenesis of allergic asthma.
Although there has been increasing evidence suggesting the involvement of IL-17 in the …

The interleukin-12 (IL-12) family comprises a group of heterodimeric cytokines and their
respective receptors that play key roles in immune responses. A growing number of …

ABSTRACT Introduction Interleukin (IL)-17 is critical in the pathogenesis of psoriasis and
psoriatic arthritis (PsA) with most data suggesting that IL-17A alone was the key cytokine …

Objective Interleukin‐23 (IL‐23) is a crucial cytokine implicated in chronic inflammation and
autoimmunity, associated with various diseases such as psoriasis, psoriatic arthritis, and …

In order to determine the mechanisms by which a chronic inflammatory network can be
maintained in the arthritic joint, we examined whether fibroblast-like synoviocytes (FLS) …

Objective. To demonstrate gene expression of interleukin (IL)-17A, IL-23, and IL-12 and to
determine the proximity of IL-17A and IL-23 producing cells in rheumatoid synovial tissue …

Advances in our understanding of the cellular and molecular mechanisms in rheumatic
disease fostered the advent of the targeted therapeutics era. Intense research activity …

IL-27, a member of the IL-12 cytokine family, is a key immunoregulatory cytokine produced
predominantly by monocytic cells and mediates innate and adaptive immune responses. IL …

ABSTRACT Introduction Interleukin 23 (IL-23) is a pro-inflammatory cytokine that plays a
protective role against bacterial and fungal infections. However, the dysregulation of the IL …

Introduction Th17 cells have been implicated in the pathogenesis of rheumatoid arthritis
(RA). The aim of this study was to systematically analyse the phenotype, cytokine profile and …