This review focuses on the contributions made by interactions between dendritic cells (DCs)
and T cells, and by local production of cytokines and chemokines to the pathogenesis of …

In this study, we investigated the effect of the antitumor necrosis factor alpha (anti-TNF-α)
antibody, infliximab, combined with methotrexate (MTX) and MTX alone on the serum levels …

Dendritic cell function is modulated by stromal cells, including fibroblasts. Although poorly
understood, the signals delivered through this crosstalk substantially alter dendritic cell …

IL-23 is the key cytokine that induces the expansion of Th17 cells. It is composed of p19 and
p40 subunits of IL-12. The p40 subunit binds competitively to the receptor of IL-23 and …

Autoimmune inflammatory diseases are primarily characterized by deregulated expression
of cytokines, which drive pathogenesis of these diseases. A number of approved and …

Cytokine-mediated immunity plays a crucial role in the pathogenesis of various autoimmune
diseases, including rheumatoid arthritis (RA). Increasing evidence has revealed the …

Current therapeutics for the treatment of rheumatoid arthritis (RA) offer limited efficacy in a
restricted number of patients. There is, therefore, an unmet clinical need for the development …

Aims: To assess the contribution of fibroblast-like synoviocytes (FLS) to the inflammatory
joint microenvironment under different pathogenic stimuli and their potential to respond to …

This study represents the first description of the cloning of chicken IL-23p19 (ChIL-23α) and
the function of the IL-23 complex in birds. Multiple alignment of ChIL-23α with other known IL …

The purpose of this study was to compare the serum interleukin (IL)-23 levels between
rheumatoid arthritis (RA) patients and healthy controls and to determine the correlation of IL …