Chronic kidney disease (CKD) is a common condition with an increasing prevalence. A
number of comorbidities are associated with CKD and prognosis is poor, with many patients …

The angiotensin II type 1 receptor (AGTR1) plays an integral role in blood pressure control,
and is implicated in the pathogenesis of hypertension. Polymorphisms within this gene have …

Deaths of participants and losses to follow-up pose challenges for defining outcomes in
epidemiologic studies. The authors compared several definitions of incident chronic kidney …

Systemic arterial hypertension is an important cause of cardiovascular disease morbidity
and mortality. African Americans are disproportionately affected by hypertension, in fact the …

Renin‐angiotensin system (RAS) polymorphisms have been studied as candidate risk
factors for hypertension with inconsistent results, possibly due to heterogeneity among …

Background. The contribution of race differences in access to health care to disparities in
chronic kidney disease (CKD) incidence in the United States is unknown. Methods. We …

Genetic variants may increase susceptibility to both diabetes and kidney disease. Whether
known diabetes-associated variants in the transcription factor 7–like 2 (TCF7L2) gene are …

Abstract Background/Aims: Some studies suggest that polymorphisms in angiotensin-
converting enzyme (ACE), angiotensinogen (AGT), angiotensin II type I receptor (AGTR1) …

Background Increased activation of the renin-angiotensin system (RAS) may be important in
promoting coronary heart disease (CHD) and renal dysfunction, but limited data are …

Renal failure has a complex phenotype resulting from an underlying kidney disease as well
as environmental and genetic factors. In the present study we performed a systematic review …