[HTML][HTML] Pathogenesis of preterm birth: bidirectional inflammation in mother and fetus
ES Green, PC Arck - Seminars in immunopathology, 2020 - Springer
Abstract Preterm birth (PTB) complicates 5–18% of pregnancies globally and is a leading
cause of maternal and fetal morbidity and mortality. Most PTB is spontaneous and idiopathic …
cause of maternal and fetal morbidity and mortality. Most PTB is spontaneous and idiopathic …
[HTML][HTML] The immunobiology of preterm labor and birth: intra-amniotic inflammation or breakdown of maternal–fetal homeostasis
In brief The syndrome of preterm labor comprises multiple established and novel etiologies.
This review summarizes the distinct immune mechanisms implicated in preterm labor and …
This review summarizes the distinct immune mechanisms implicated in preterm labor and …
Single cell transcriptional signatures of the human placenta in term and preterm parturition
More than 135 million births occur each year; yet, the molecular underpinnings of human
parturition in gestational tissues, and in particular the placenta, are still poorly understood …
parturition in gestational tissues, and in particular the placenta, are still poorly understood …
[HTML][HTML] Maternal-fetal immune responses in pregnant women infected with SARS-CoV-2
Pregnant women represent a high-risk population for severe/critical COVID-19 and mortality.
However, the maternal-fetal immune responses initiated by SARS-CoV-2 infection, and …
However, the maternal-fetal immune responses initiated by SARS-CoV-2 infection, and …
[HTML][HTML] Macrophages exert homeostatic actions in pregnancy to protect against preterm birth and fetal inflammatory injury
N Gomez-Lopez, V Garcia-Flores, PY Chin… - JCI insight, 2021 - ncbi.nlm.nih.gov
Macrophages are commonly thought to contribute to the pathophysiology of preterm labor by
amplifying inflammation—but a protective role has not previously been considered to our …
amplifying inflammation—but a protective role has not previously been considered to our …
[HTML][HTML] Steroids, pregnancy and fetal development
ME Solano, PC Arck - Frontiers in immunology, 2020 - frontiersin.org
Maternal glucocorticoids critically rise during pregnancy reaching up to a 20-fold increase of
mid-pregnancy concentrations. Concurrently, another steroid hormone, progesterone …
mid-pregnancy concentrations. Concurrently, another steroid hormone, progesterone …
[PDF][PDF] Regulatory T cells play a role in a subset of idiopathic preterm labor/birth and adverse neonatal outcomes
Regulatory T cells (Tregs) have been exhaustively investigated during early pregnancy;
however, their role later in gestation is poorly understood. Herein, we report that functional …
however, their role later in gestation is poorly understood. Herein, we report that functional …
Inflammasomes: their role in normal and complicated pregnancies
Inflammasomes are cytoplasmic multiprotein complexes that coordinate inflammatory
responses, including those that take place during pregnancy. Inflammasomes and their …
responses, including those that take place during pregnancy. Inflammasomes and their …
A key role for NLRP3 signaling in preterm labor and birth driven by the alarmin S100B
Preterm birth remains the leading cause of neonatal morbidity and mortality worldwide. A
substantial number of spontaneous preterm births occur in the context of sterile intra …
substantial number of spontaneous preterm births occur in the context of sterile intra …
[HTML][HTML] Functional regulation of decidual macrophages during pregnancy
F Sun, S Wang, M Du - Journal of reproductive immunology, 2021 - Elsevier
A successful pregnancy requires that the maternal immune system recognizes and tolerates
the semi-allogeneic fetus without compromising the capability of protecting both mother and …
the semi-allogeneic fetus without compromising the capability of protecting both mother and …